CAS: 132-93-4; Phenethicillin Potassium
该化合物是一种主要用于抗菌特性的半合成二硝基苯丙胺抗生素,其特征是能够抑制细菌细胞壁合成,使其对一系列抗模性细菌有效;该化合物通常以钾盐的形式施用,这增加了其溶性性和生物利用率;苯乙基林在气酸条件下具有稳定性,允许口服;其化学结构包括乙硫基苯环,这是其抗微生物活动必不可少的;该物质一般具有良好的耐用性,但与其他抗生素一样,可能会在一些人中引起过敏反应或胃肠紊乱;必须明智地使用这种抗生素来防止抗生素抗体的发育;与所有药物一样,该物质应当由保健专业人员开具,其使用应当以易感测试为指导,以确保有效防治目标细菌感染.
- 英文名称Phenethicillin Potassium
- 中文名称苯氧乙基青霉素钾
- IUPAC名称3,3-Dimethyl-7-oxo-6-((1-oxo-2-phenoxypropyl)amino)-4-thia-1-azabicyclo(3.2.0)-heptane-2-carboxylic acid potassium salt
- 其它别名ALPHA-PHENOXYETHYLPENICILLINIC ACID POTASSIUM SALT; PHENETHICILLIN POTASSIUM; PHENETHICILLIN POTASSIUM SALT; (2s-(2alpha,5alpha,6beta))-nopotassiumsal; 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxypropyl)amino]-4-thia-1-azabicyclo[3.2.0]; 3,3-dimethyl-7-oxo-6--4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacimo; 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-(2-p; 6-(a-phenoxypropionamido)penicillanicacidpotassiumsalt
- CAS编号132-93-4
- MFCD编号:MFCD00082379
- EINECS号:205-084-4
- FDA UNII编号:70978WUK7C
- 分子式:C17H19KN2O5S分子量:402.51
- 产品CID: 495418
- 同类组份化合物CAS147-55-7 (free)132-93-4 (potassium)
- 产品分类原料药 → 抗生素类药物 → 青霉素类药
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
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专利信息
专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.
专利号:EP-1976815-B1
优先权日:2006-01-11
标 题:Synthesis of biodiesel using alkali ion conductive ceramic membranes
发明人：BALAGOPAL SHEKAR; JOSHI ASHOK; PENDELTON JUSTIN
权利人:CERAMATEC INC
摘要:Methods and apparatus for synthesizing biodiesel (40) using alkali alkoxide (30) generated on-site using an electrochemical process are disclosed. The apparatus and methods are disclosed to converting alkali salts of glycerine into glycerine and thereby facilitate the separation of clean glycerine (72) from biodiesel (70). These methods are enabled by the use of alkali ion conductive ceramic membranes (16 and 42) in electrolytic cells (12 and 14).
专利号:US-2007158205-A1
优先权日:2006-01-11
标题:Synthesis of Biodiesel Using Alkali Ion Conductive Ceramic Membranes
专利号:CN-1626662-A
优先权日:1994-06-08
标题 :Genes for the synthesis of antipathogenic substances
专利号:EP-1976815-A2
优先权日:2006-01-11
标 题:Synthesis of biodiesel using alkali ion conductive ceramic membranes
专利号:WO-2007082092-A2
优先权日:2006-01-11
标题:Synthesis of biodiesel using alkali ion conductive ceramic membranes
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主要参考文献
1: MARTIN WJ, NICHOLS DR. Penicillin V and phenethicillin potassium in serum: comparison of concentrations and of antibacterial effects. Proc Staff Meet Mayo Clin. 1960 Sep 28;35:577-84.
3: SABATINE JW, KARP A, FREEMAN SL. Phenethicillin vs. potassium penicillin G for ear, nose, and throat infections. Eye Ear Nose Throat Mon. 1963 May;42:53-4. French.
合成参考文献
摘要:Research Progress in Organic-Biological and Medicinal Chemistry., 2(311), 1970
摘要:Arzneimittel-Forschung. Drug Research., 12(751), 1962 []
摘要:Haddad, L.M., Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: W.B. Saunders Co., 1990., p. 953
摘要:Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 1146
摘要:Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 1070
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