CAS: 124-65-2; Sodium Dimethylarsinate

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CAS号593-58-8 甲基氧化胂 | CAS号74-88-4 碘甲烷 | CAS号593-57-7 dimethylarsine | CAS号471-35-2 tetramethyldiarsine | CAS号503-80-0 dimethylarsanyl...

专利信息

专利号:US-5714587-A
优先权日:1993-03-31
标 题 :Synthesis of anti-inflammatory compounds, and novel trisaccharides useful in the synthesis of anti-inflammatory compounds
发明人：LAINE ROGER A
权利人:UNIV LOUISIANA STATE; AGRICULTURAL AND MECHANICAL CO
摘要:Anti-inflammatory compounds are useful, for example, in treating arthritis and heart attack patients. Novel oligosaccharides useful in the rapid synthesis of certain anti-inflammatory compounds are disclosed, as is a rapid method of synthesizing the oligosaccharides. Low pH can loosen the acceptor specificity of galactosyltransferase (lactose synthase: EC 2.4.1.22), allowing the rapid synthesis of novel oligosaccharides. The disaccharides cellobiose (β1→4), laminaribiose (β1→3), gentiobiose (β1→6) and maltose (α1→4) acted as acceptors for lactose synthase under low pH conditions. From these four acceptors, the following four novel trisaccharides were synthesized: Gal p (β1→4)Glc p (β1→3) -Glc, Gal p (β1→4)Glc p (β1→4)-Glc, Gal p (β1→4)Glc p (β1→6)-Glc and Gal p (β1→4)Glc p (α1→4)Glc. These trisaccharides, and other oligosaccharides, may be synthesized in a few days with the disclosed technique, as opposed to the several months which would likely have been required with more traditional organic synthetic methods. These trisaccharides may be used as intermediates in the rapid synthesis of anti-inflammatory compounds.

专利号:US-2022218741-A1
优先权日:2019-05-31
标 题 :Cell-Mediated Synthesis of Noble Metal Oxide Nanoparticles and Biomedical Applications Thereof
发明人：CRUZ DAVID MEDINA; CHEN JUNJIANG; WEBSTER THOMAS J
权利人:UNIV NORTHEASTERN
摘要:Human dermal fibroblasts (HDF) and melanoma (MEL) cells are used herein for synthesis of metal nanoparticles. For example, synthesis of nanoparticles of gold (Au), palladium (Pd), platinum (Pt), and bimetallic formulations of gold-palladium (AuPd) and gold-platinum (AuPt) is demonstrated with HDF and MEL using a straightforward, eco-friendly and cost-effective approach. The nanostructures are purified and used in biomedical tests, which show selective behavior. The production of nanoparticles allows for stopping of the growth of cancer cells and the ability of new healthy cells to grow on top. The production of nanoparticles with the cells allows for an environmental-resistance behavior within the cells, showing the ability to stand for extreme environmental conditions.

专利号:US-9938312-B2
优先权日:2011-03-25
标题 :Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
发明人：BOONS GEERT-JAN; WANG ZHEN
权利人:BOONS GEERT JAN; WANG ZHEN; UNIV GEORGIA
摘要:The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.

专利号:US-5352670-A
优先权日:1991-06-10
标题:Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
发明人：VENOT ANDRE P; UNGER FRANK M; KASHEM MOHAMMED A; BIRD PAUL; MAZID M ABDUL
权利人:ALBERTA RES COUNCIL
摘要:Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.

专利号:US-2003170828-A1
优先权日:2000-08-22
标 题 :Synthesis of complex carbohydrates
发明人：ZOU WEI; JENNINGS HAROLD J
摘要:A tailor-assembly approach is employed for synthesis of complex carbohydrates wherein a polysaccharide is degraded and the shorter product obtained from the degradation is subjected to enzymatic modification to add a sugar moiety. The products may be useful in the preparation of a cancer vaccine. In one example, oligosaccharides of the type Ia group B Streptococcus (GBSIa) capsular polysaccharide and multivalent sialyl Le x antigens are specifically described. GBSIa polysaccharide was depolymerized by partial Smith degradation to fragments representing asialo core repeating units. Enzymatic sialylation of these oligomers furnished GBSIa repeating units (from monomer to pentamer). Fucosylation on GlcNAc residues of GBSIa oligomers afforded oligosaccharides that carry multiple sialyl Le x epitopes.

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.