CAS: 121748-11-6; (1S,2S)-1-(4-Hydroxy-3,5-Dimethoxyphenyl)Propane-1,2,3-Triol

上下游产品

-essigsaeure-ethylesterα-Acetoxy-α-3,5-dimethoxy-4-acetoxy-benzoyl-essigsaeure-ethylester 3,5-Dimethoxy-4-acetoxy-benzoylessigsaeure-aethylester ethyl 2-bromo-3-(4-acetoxy-3,5-dimethoxyphenyl)-3-oxopropionate 9-(6-O-[(2E,6S)-2,6-dimethyl-6-hydroxy-2,7-°Ctadienoyl]-β-D-glucopyranosyloxy)syringoylglycerol

专利信息

专利号:US-10456387-B2
优先权日:2011-11-29
标 题:Phacetoperane for treating of attention deficit hyperactivity disorder
发明人：KONOFAL ERIC; FIGADERE BRUNO
权利人:NLS PHARMA AG; NLS PHARMACEUTICS AG
摘要:The invention relates to the treatment of an attention deficit hyperactivity disorder (ADHD) with alpha-phenyl(piperidin-2-yl)methanol, or the pharmaceutically acceptable salts and esters thereof, in particular the acetate derivative, more particularly dextrophacetoperane. The invention additionally provides a method of synthesis of the (S,S) enantiomer of alpha-phenyl(piperidin-2-yl)methanol as well as a method of synthesis of dextrophacetoperane.

专利号:US-5962737-A
优先权日:1997-01-08
标 题 :2-amino-1-phenylpropanols, stereospecific synthesis thereof, and method of optically resolving the same
发明人：WEST DANIEL DAVID
摘要:Stereospecific synthesis of the racemic threo isomers of 2-nitro-1-phenylpropanols by reacting a benzaldehyde derivative with nitroalkane in the presence of a tertiary amine and reducing 2-nitro-1-phenylpropanols with, for example, lithium aluminum hydride to 2-amino-1-phenylpropanols is described. Also described are phase transfer resolution of racemic mixtures of 2-amino-1-phenylpropanol and its derivatives into their optically pure isomers by reacting a racemic mixture with the mono alkali metal salt of a tartaric acid ester in a two phase system of a hydrocarbon and water. The specification further describes therapeutically useful optically pure isomers of threo-2-amino-1-(dialkoxy or alkoxy) phenylpropanols and acid addition salts thereof.

专利号:US-3708477-A
优先权日:1968-06-27
标 题:Process of total synthesis of cephalosporin derivatives and intermediates
发明人：MARTEL J; HEYMES R
权利人:ROUSSEL UCLAF
摘要:PROCESS FOR THE PREPARATION OF RACEMIC OR OPTICALLYACTIVE CEPHALOSPORINE DERIVATIVES OF THE FORMULA 2,3-(-CO-N(-R1)-CH2-),7-NH2-2-CEPHEM WHEREIN R1 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL, SUBSTITUTED AKYL, ARYL AND SUBSTITUTED ARYL, WHICH COMPRISES THE STEPS OF REACTING AN AMINO ACID OF THE FORMULA R1-NH-CH2-CH2-COOH WITH BENZYL ALCOHOL, CONDENSING THE BENZYL ESTER THUS OBTAINED WITH AN OXALATE, CONVERTING THE BENZYL ESTER OF 2,3DIOXI-4-CARBOXY-PYRROLIDINE INTO THE CORRESPONDING ACID, SUBJECTING SAID ACID TO AMINOMETHYLATION, THUS YIELDING A COMPOUND OF THE FORMULA 1-R1,3-OH,4-(R'-N(-R'')-CH2-)PYRROL-3-IN-2-ONE CONVERTING SAID COMPOUND INTO THE CORRESPONDING 4-ACYLTHIOMETHYL DERIVATIVE, CONVERTING SAID DERIVATIVE INTO THE CORRESPONDING 4-THIOMETHYL DERIVATIVE, CONDENSING SAID DERIVATIVE WITH AN ENAMINE OF THE FORMULA R-OOC-C(-Y)=CH-NH2 TO OBTAIN A THIAZINE DERIVATIVE OF THE FORMULA 2-(Y-CH(-COO-R)-),5-R1-2,3,4,5,6,7-HEXAHYDRO-PYRROLO (3,4-D)-1,3-THIAZIN-4-ONE CONVERTING SAID THIAZINE DERIVATIVE INTO A COMPOUND OF THE FORMULA 2-(H2N-CH(-COOH)-),5-R1-2,3,4,5,6,7-HEXAHYDRO-PYRROLO (3,4-)-1,3-THIAZIN-4-ONE SUBJECTING SAID COMPOUND TO THE ACTION OF A TRITYLATION AGENT, RECOVERING THE THREO ISOMER OF THE TRITYLATED DERIVATIVE, LACTAMIZING SAID THREO ISOMER TO OBTAIN THE Y-LACTAM OF DL-6H,7H-CIS-7-TRITYLAMINO-3-AMINOALKYL-CEPH 3-EME-4-CARBOXYLIC ACID, DETRITYLATING SAID Y-LACTAM AND RECOVERING SAID RACEMIC OF OPTICALLY ACTIVE CEPHALOSPORIN DERIVATIVES. THESE COMPOUNDS ARE USEFUL AS INTERMEDIATES IN THE PREPARATION OF THE CORRESPONDING 7ACYLAMINO DERIVATIVES OF THE FORMULA 2,3-(-CO-N(-R1)-CH2-),7-(R2-NH-)-2-CEPHEM WHEREIN R1 HAS THE ABOVE DEFINITION AND R2 IS THE ACYL OF AN ORGANIC CARBOXYLIC ACID WHICH COMPOUNDS ARE ALSO PART OF THE INVENTION AND ARE USEFUL AS ANTIBIOTICS.

专利号:US-3694464-A
优先权日:1968-07-10
标 题 :PREPARATION OF 1-ACETOXY-3-(ALKYL)-6,6,9-TRIMETHYL-7,8,9,10-TETRAHYDRO-6H-DIBENZO{8 b,d{9 {0 PYRAN ISOMERS
发明人：AARON HERBERT S; FERGUSON CLYDE PARKER JR
权利人:US ARMY
摘要:A novel process and novel intermediates in the synthesis of the novel optically-active isomers of 1-acetoxy-3(alkyl)-9-methyl7,8,9,10-tetrahydro-6H-dibenzo (b,d)pyran as incapacitating agents. Those intermediates are prepared by reducing a mixture comprising a ketone, an alcohol and borohydride to the carbinol, treating said carbinol with a trihalide and converting the trihalide product to a malonic ester, hydrolyzing said ester and separating the aqueous phase, acidifying said aqueous phase results in the preparation of an isomeric mixture of alkyldialkoxyhydrocinnamic acid.

专利号:EP-0415384-B1
优先权日:1989-08-31
标题 :Heterogeneous synthesis of azepinones from esters
发明人：MARTIN DANIEL E
权利人:HOECHST MARION ROUSSEL INC
摘要:An amino-acid ester compound can be cyclized into a cyclic amido-carbonyl compound by contacting the amino-acid ester compound in a liquid medium with a heterogeneous acidic ion-exchange substance. For example, 2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid, methyl ester, threo form, can be cyclized in an aqueous mixture into cis-2-(4-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H) -one by employing a sulfonated polystyrene-divinylbenzene ion-exchange resin in its acid form, e.g., Dowex 50X4-400, at yields exceeding 85 percent of theory, and the product can be used to make diltiazem hydrochloride.

专利号:US-5250680-A
优先权日:1989-08-31
标题:Heterogeneous synthesis of azepinones from esters
发明人：MARTIN DANIEL E
权利人:MERRELL DOW PHARMA
摘要:An amino-acid ester compound can be cyclized into a cyclic amido-carbonyl compound by contacting the amino-acid ester compound in a liquid medium with a heterogeneous acidic ion-exchange substance. For example, 2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid, methyl ester, threo form, can be cyclized in an aqueous mixture into cis-2-(4-methoxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one by employing a sulfonated polystyrene-divinylbenzene ion-exchange resin in its acid form, e.g., Dowex® 50X4-400. at yields exceeding 85 percent of theory, and the product can be used to make diltiazem hydrochloride.