CAS: 112160-39-1; 2,2,5,7,8-Pentamethylchroman-6-Sulfonyl Chloride
该化合物是有机合成中使用的一种专门的磺酰激素试剂,特别是用于将磺酸盐组引入目标分子,其染色体骨骼具有更强的稳定性,而五甲基替代模式则提高了全氟辛烷磺酸反应的活性性和选择性.该化合物在硫化物化学和制药中间体中特别有用,有利于在温和条件下有效衍生.对甲基电镀组进一步加强其与敏感子质的兼容性.其高纯度和一贯性能使它成为需要复杂的合成路径精确的全氟辛烷磺酸研究人员的可靠选择.
- 英文名称2,2,5,7,8-Pentamethylchroman-6-Sulfonyl Chloride
- 中文名称2,2,5,7,8-五甲基苯并二氢吡喃-6-磺酰氯
- IUPAC名称2,2,5,7,8-pentamethylchromane-6-sulfonyl chloride
- 其它别名3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-磺酰氯; Pmc-Chloride
- CAS编号112160-39-1
- MFCD编号:MFCD00065693
- EINECS号:626-998-3
- 分子式:C14H19ClO3S分子量:302.82
- 产品CID: 155502
- 产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物
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MSDS等安全信息
欧盟法规
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2,2,5,7,8-五甲基色满 2,2,5,7,8-Pentamethylchroman 55646-01-0合成工艺路线路线简述
📜2,3,5-三甲基苯酚置于氯磺酸,Zinc(II) Chloride体系中,用 氯仿,溶剂黄146 用作溶剂,化学反应 20.25H,反应生成2,2,5,7,8-五甲基苯并二氢吡喃-6-磺酰氯
参考文献:用于肽合成的酸不稳定的精氨酸衍生物:N G-2,2,2,5,7,8-五甲基苯并吡喃-6-磺酰基-L-精氨酸
标题:用于肽合成的酸不稳定的精氨酸衍生物:N G-2,2,2,5,7,8-五甲基苯并吡喃-6-磺酰基-L-精氨酸
摘要:已经开发出用于精氨酸的胍侧链功能的三氟乙酸(tfa)不稳定的保护基.ñ ģ-(2,2,5,7,8-五甲基-6-磺酰基-L-精氨酸在室温下迅速裂解以tfa或50%tfa的二氯甲烷溶液fmoc.Arg(pmc).oh的制剂和描述了bnpeoc.Arg(pmc).Oh.
Doi:10.1016/s0040-4020(01)86564-9
海关参考信息
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2905122000-异丙醇
2905143000-叔丁醇
2905142000-仲丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.
专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.
专利号:US-8846614-B2
优先权日:2011-08-25
标 题 :Process for the synthesis of 37-mer peptide pramlintide
发明人：MOHE NIKHIL UMESH; CHAVRE PRAFUL SHAMRAO; DESHMUKH BHARTI PRABHAKARRAO; MURALIDHARAN CHANDRAKESAN; LOBO LESTER JOHN; PAWAR DIGAMBER SHRIPATI; SAKSENA DIVYA LAL
权利人:MOHE NIKHIL UMESH; CHAVRE PRAFUL SHAMRAO; DESHMUKH BHARTI PRABHAKARRAO; MURALIDHARAN CHANDRAKESAN; LOBO LESTER JOHN; PAWAR DIGAMBER SHRIPATI; SAKSENA DIVYA LAL; USV LTD
摘要:A process for the production of pramlintide, a 37-mer peptide, is provided. The synthesis provides a high yield synthesis of the peptide in relatively pure form. Further purification can be achieved by preparative HPLC.
专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.
专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.
专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题: Thiosemicarbazates And Uses Thereof Thiosemicarbazates Et Leurs Utilisations摘要:Thioesters, Thiocarbamates, Thiocarbazates, Semithiocarbazates, Peptides, Aza-Amino Acid Conjugates, And Azapeptides; And A Chemoselective And Site-Specific Functionalization Protocol Of Protected Thiocarbazates And Semithiocarbazates Are Described. The Protocol Features The Use Of Mitsunobu Reaction To Alkylate Specifically The Nitrogen Atom Close To The Acylthiol Moiety With Alcohols To Produce Protected Mono-Substituted Thiocarbazates That Can Be Stored For Months, Activated Under Mild Conditions At Low Temperature Using Halonium Reagents And Integrated Orthogonally To Make Substituted Semicarbazides That Can Be Used, E.G., As Synthons In Synthesis Of Aza-Amino Acid Conjugates, Azapeptides And Other Peptidomimetics. Methods For Preparing And Using Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides, And Other Peptidomimetics And Azapeptide Conjugates, And Uses Of Ureases, Carbazides, Semicarbazides, Beta-Peptides, Azapeptides In Drug Discovery, Diagnosis, Inhibition, Prevention And Treatment Of Diseases Are Also Described.
合成参考文献
参考文献:10.1055/s-2007-983706
摘要:Madalengoitia J, Flemer S. Synthetic Routes to N-Pmc-N′,N′′-Disubstituted Guanidines via EDCI-Mediated Guanylation of Amines with N-Pmc-N′-Substituted Thioureas. Synthesis. 2007 Jun;2007(12):1848–60. doi: 10.1055/s-2007-983706.
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