CAS: 1010-60-2; 2-Chloronaphthalene-1,4-Dione

上下游产品

CAS号130-15-4 1,4-萘醌 | CAS号83-72-7 2-羟基-1,4萘醌 | CAS号1515-76-0 1-乙酰氧基-1,3-丁二烯 | CAS号615-67-8 氯氢醌 | CAS号91-58-7 β-氯萘 | CAS号2395-97-3 9,10-Dimethoxya... | CAS号2050-76-2 2,4-二氯-1-羟基萘 | CAS号571-60-8 1,4-萘二酚 | CAS号10075-62-4 1,4-二甲氧基萘 | CAS号10383-63-8 Anthraquinone, ... | CAS号106261-76-1 2,2-dimethyl-1H... | CAS号106261-79-4 2a-chloro-1,1-d... | CAS号84-54-8 2-甲基蒽醌 | CAS号25007-57-2 2-chloro-3-phen... | CAS号84-79-7 黄钟花醌 | CAS号130-15-4 1,4-萘醌 | CAS号95233-18-4 阿托伐醌 | CAS号602-64-2 媒染棕18 | CAS号605-32-3 2-羟基蒽醌

1,4-萘醌置于氯,Mercury(II) Oxide体系中,用 四氯化碳 用作溶剂,化学反应 0.5H,以100%的收率获得2-氯-1,4-萘醌
参考文献:用一氧化二氯氯化醌类化合物
标题:用一氧化二氯氯化醌类化合物
摘要:摘要 一氧化二氯是苯醌类和萘醌类中活性醌类位置单氯化的选择性试剂.
Doi:10.1080/00397919408011701

专利信息

专利号:WO-2012153162-A1
优先权日:2011-05-12
标题 :Novel method for preparation of atovaquone
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; TRIVEDI ANURAG
摘要:Provided is a process of preparation of 2-[ trans ,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy- 1,4-naphthoquinone, i.e. Atovaquone [I] which is cost effective, green, and eco-friendly process, without separation of any diastereomers or geometric isomers of intermediates obtained during the reactions. Also provided is separation of ' cis ' and ' trans ' isomer of intermediates VI, VII and VIII through selective crystallization in an appropriate solvent. A method for converting 2-[ cis ,-4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone to 2-[ trans -4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone in presence of Lewis/ Bronsted acid is also provided. A process for preparation of compound 2-(4-(4- chlorophenyl)- 1 -hydroxy cyclohexyl)-3,4-dihydronaphthalen- 1 (2H)-one [IV] comprising condensation of (1,2-dihydronaphthalen-4-yloxy)trimethylsilane [II] with 4-(4- chlorophenyl)cyclohexanone [III] in presence of Lewis acid in organic solvent. The invention also encompasses a highly efficient and atomeconomic process for synthesis of compound [III] i.e. 4-(4-chlorophenyl)cyclohexanone as well as a process for synthesis of 2-[ cis -4-(4'- chlorophenyl)cyclohexyl]-3-hydroxy-l,4-naphthoquinone. Further provided is a process for isomerization of cis- Atovaquone i.e. 2-[ cis -4-(4'-chlorophenyl)cyclohexyl]-3-hydroxy-l,4- naphthoquinone to tnms-Atovaquone i.e. 2-[ trans -4-(4'-chlorophenyl)cyclohexyl]-3- hydroxy- 1,4-naphthoquinone in presence of Lewis acid.

专利号:US-7544794-B1
优先权日:2005-03-11
标题 :Method for sequencing DNA and RNA by synthesis
发明人：BENNER STEVEN ALBERT
权利人:BENNER STEVEN ALBERT
摘要:This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that are nucleic acid analogs. More specifically, this invention relates to compositions that allow the sequencing of oligonucleotides by synthesis, and processes for sequencing by synthesis that exploit these compositions. Most specifically, the instant invention discloses compositions of matter that are 5′-triphosphates of ribo- and 2′-deoxyribonucleosides wherein the 3′-OH group is replaced by a 3′-ONHR group in the alpha configuration, wherein R is either a H or CH 3 group. Also disclosed are these triphosphates where the nucleobase carries, via a linker, a reporter groups, such as a fluorescent species that can be used in single- or multi-copy DNA sequencing, or a tag that can be visualized by ultramicroscopy. Also disclosed are processes that use these compositions to do sequencing by synthesis.

专利号:CN-102321891-A
优先权日:2011-09-19
标题:A high-yield electrochemical method for the synthesis of 2,2'-dichlorohydroazobenzene

专利号:US-8466157-B2
优先权日:2009-03-06
标题:Proteasome inhibitors having chymotrypsin-like activity
发明人：LAWRENCE HARSHANI; GE YIYU; SEBTI SAID M; GUIDA WAYNE
权利人:LAWRENCE HARSHANI; GE YIYU; SEBTI SAID M; GUIDA WAYNE; UNIV SOUTH FLORIDA; H LEE MOFFITT CANCER CT & RES
摘要:Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step protocol and the method was further optimized to a two step protocol. The synthesis in both protocols was regioselective with TiCl 4 . The reaction was highly efficient with microwave assisted heating and THF as solvent. The modification around the molecule HLM-008182 established primary SAR, indicating that the proteasome inhibition activity was a function of the 2-side chain.

专利号:CN-116874360-A
优先权日:2023-09-06
标 题:A kind of synthesis method of bupavaquone

专利号:CN-116874360-B
优先权日:2023-09-06
标题:A kind of synthesis method of bupavaquone