CAS: 10071-13-3; 6-Amino-3(2H)-Pyridazinone

专利信息

专利号:US-5206392-A
优先权日:1992-04-27
标 题:Facile synthesis of arylmaleic acids and anhydrides
发明人：DEAN WILLIAM D
权利人:AMERICAN CYANAMID CO
摘要:A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonitriles with glyoxylic acid to provide novel intermediate 3-aryl-3-cyanopropeneoates which may be converted to the arylmaleic acid and arylmaleic anhydride derivatives.

专利号:WO-2008150031-A1
优先权日:2007-06-08
标题:Inhibitor of biosynthesis of plant hormone auxin, chemical plant regulator comprising the inhibitor as active ingredient, herbicidal agent, and use thereof
发明人：SHIMADA YUKIHISA; GODA HIDEKI; TACHIKAWA TOMOE; ISHII TAKAHIRO; SOENO KAZUO; FUJIOKA SHOZO; ASAMI TADAO
权利人:RIKEN; SHIMADA YUKIHISA; GODA HIDEKI; TACHIKAWA TOMOE; ISHII TAKAHIRO; SOENO KAZUO; FUJIOKA SHOZO; ASAMI TADAO
摘要:The first object is to provide an inhibitor of the synthesis of endogenous auxin. The second object is to provide a plant growth inhibitor or a herbicidal agent utilizing the auxin biosynthesis inhibitor. Thus, disclosed are: a method for screening a candidate for an auxin biosynthesis inhibitor capable of inhibiting the expression of an auxin-inducible gene, by adding each of candidate compounds for the auxin inhibitor to a plant; a method for selecting a compound capable of actually inhibiting the auxin synthesis in a plant, by adding each of candidate compounds to the plant, disrupting the plant and then measuring the amount of endogenous auxin; and a method for selecting a compound capable of inhibiting the production of indolpyruvic acid in the presence of a tryptophan deaminase and tryptophan which are prepared in advance. More specifically disclosed are: an auxin biosynthesis inhibitor comprising AVG, AOA, AOIBA, L-AOPP or an analogue thereof; and a plant growth regulator or a herbicidal agent comprising the compound as an active ingredient.

专利号:US-2008312430-A1
优先权日:2004-10-20
标题:Method of Preparing or Synthesizing Polyazamacrocycle Derivatives
发明人：CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention relates to novel processes for the synthesis of polyazamacrocycle derivatives. Furthermore, the present invention relates to novel polyazamacrocycle derivatives as well as novel intermediates for the synthesis of said polyazamacrocycle derivatives.

专利号:US-2005239808-A1
优先权日:2002-05-10
标题 :Active substances for the treatment, diagnosis and prophylaxis of diseases in which abnormal protein structures occur
发明人：SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA
权利人:SCHRADER THOMAS; RIESNER DETLEV; RZEPECKI PETRA; NAGEL-STEGER LUITGARD; WEHNER MARK; KIRSTEN CHRISTIAN; MOLT OLIVER; ZADMARD REZA; ASCHERMANN KATJA
摘要:The invention on hand refers to diseases associated with abnormal protein structures, including Alzheimer's disease, Creutzfeldt-Jakob's disease, BSE and other prion-associated diseases. It is the task of the invention on hand to provide new active agents preventing the formation of amyloid plaques and to dissolve existing plaques, such agents being convenient for therapy, diagnosis and prophylaxis of diseases that are associated with abnormal protein structures. This task is performed in terms of the current invention by heterocyclic or aromatic agents with a rigid structure and a donor-acceptor-donor pattern (DAD), the latter being formed by donors and acceptors of hydrogen bridge linkages which comply with the β-sheet structure of the peptide or protein and thus fit as binding partners. The heterocyclic or aromatic agents are available at least as dimers. They recognise peptides and proteins with a β-sheet structure, form stable complexes with them and inhibit their aggregation to β-amyloid plaques. Furthermore, the new active agents are able to dissolve β-amyloid plaques that already exist. Another task of the current invention is to provide methods for the synthesis of said heterocyclic or aromatic compounds.

专利号:WO-0107415-A1
优先权日:1999-07-28
标 题 :Method of producing pyridazine-3,6-dicarboxylic acid esters
发明人：BESSARD YVES; CRETTAZ ROGER; BRIEDEN WALTER
权利人:LONZA AG; BESSARD YVES; CRETTAZ ROGER; BRIEDEN WALTER
摘要:The invention relates to a method of producing pyridazine-3,6-dicarboxylic acid esters of the general formula (I), wherein R represents C1-10 alkyl, C3-8 cycloalkyl or aryl-C1-4-alkyl, by reacting 3,6-dichloropyridazine with carbon monoxide and alcohols R-OH in the presence of palladium-phosphine complexes and bases. The invention also relates to novel pyridazine-3,6-dicarboxylic acid esters (I), wherein R represents C3-10 alkyl, C3-8 cycloalkyl or aryl-C<1-4>-alkyl. The pyridazine-3,6-dicarboxylic acid esters (I) are the potential intermediates for the synthesis of pharmaceutical active substances.

专利号:US-2006115536-A1
优先权日:2004-11-12
标 题 :Glycerin based synthesis of silver nanoparticles and nanowires
发明人：YACAMAN MIGUEL J; ELECHIGUERRA JOSE L; BURT JUSTIN L; MORONES JOSE R; LOPEZ LETICIA L
权利人:UNIV TEXAS
摘要:The present invention includes compositions and methods for the production of noble metal nanoparticles and nanowires conjugated to polyols or polymers. The present invention allows the incorporation of noble metal nanoparticles to a wide range of products such as body care products to exploit the biocidal properties of silver nanoparticles against bacteria, viruses and fungi.