CAS: 92525-10-5; 3-Iodo-1-Methyl-1H-Pyrazole

相似化合物

1233513-13-7 34091-51-5 1202781-34-7

上下游产品

CAS号4522-35-4 3-碘吡唑 | CAS号74-88-4 碘甲烷 | CAS号92524-98-6 trimethyl-(1-me...

N-甲基-3-氨基吡唑置于盐酸,Sodium Nitrite,Sodium Iodide体系中,用 水 作为反应溶剂,化学反应 4.83H,以0.5 G的收率获得产物3-碘-1-甲基-1H-吡唑
参考文献:一种化合物及其制备方法和医药上的应用
标题:一种化合物及其制备方法和医药上的应用
摘要:本发明提供了一种化合物及及其制备方法和医药上的应用,所述化合物具有通式(I)所示的结构,还可为所述化合物的互变异构体,内消旋体,外消旋体,对映异构体,非对映异构体,或其混合物形式,或其可药用盐.本发明提供的具有通式(I)结构的化合物通过选择特定的主链结构以及其相应的取代基,使得得到的化合物能够作为精氨酸酶抑制剂,且活性较高,在多种疾病中具有潜在的治疗前景.

专利信息

专利号:WO-2024233848-A1
优先权日:2023-05-10
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-11787803-B2
优先权日:2017-09-15
标 题 :Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
发明人：SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; DOWNING JENNIFER R; ERICSSON ANNA
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-9192612-B2
优先权日:2013-02-13
标题:Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
发明人：BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; BECK ELIZABETH MARY; DAVOREN JENNIFER ELIZABETH; LACHAPELLE ERIK ALPHIE; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 and R 2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.