CAS: 873305-35-2; (S)-5,6-Diphenyl-N-((Tetrahydrofuran-2-yl)Methyl)Furo[2,3-D]Pyrimidin-4-Amine

上下游产品

4-Bromo-5,6-Diphenyl-Furo[2,3-D]Pyrimidine 873306-32-2
4-氯-5,6-二苯基呋喃并[2,3-D]嘧啶 4-Chloro-5,6-Diphenylfuro[2,3-D]Pyrimidine 65148-07-4

📜2-氨基-4,5-二苯基-3-呋喃甲腈置于乙酸酐,溶剂黄146,三氯氧磷体系中,用 乙醇 作为反应溶剂,化学反应 26.0H,反应生成 5,6-二苯基-N-[[(2S)-四氢-2-呋喃基]甲基]呋喃并[2,3-D]嘧啶-4-胺; Aim 100
参考文献:Methods For The Treatment Of Disorders Related To Phosphorylation Of Histones
标题:Methods For The Treatment Of Disorders Related To Phosphorylation Of Histones
摘要:用于疾病诊断,预后和治疗选择的方法.还公开了用于这些方法的组合物和选择的治疗方法.

专利信息

专利号:CN-108379591-B
优先权日:2018-04-03
标 题 :Synthesis of Immune Agonist Targeting Compounds and Their Applications

专利号:US-11285169-B2
优先权日:2013-03-13
标题 :Methods for modulating chemotherapeutic cytotoxicity
发明人：ROBERTS DAVID D; SOTO PANTOJA DAVID R
权利人:US HEALTH
摘要:Methods of reducing cytotoxicity of a chemotherapeutic agent to non-cancer cells by administering to a subject with cancer an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent, such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are provided. Example disclosed methods reduce cardiotoxicity. In one example, the methods include administering to a subject with cancer an effective amount of a CD47 antisense morpholino oligonucleotide and an anthracycline such as doxorubicin. Methods of increasing cytotoxicity of a chemotherapeutic agent in cancer cells by administering to a subject with a tumor an effective amount of an agent that inhibits CD47 signaling and a DNA damaging agent such as an anthracycline, topoisomerase inhibitor, or nucleotide synthesis inhibitor, are also provided. In some embodiments, the inhibitor of CD47 signaling is administered to the subject before, during, or after the administration of the DNA damaging agent.