CAS: 73035-16-2; 3-Acetylbenzenesulfonyl Chloride

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CAS号111711-76-3 1-(3-acetylphen...

📜间氨基苯乙酮置于盐酸,Sodium Nitrite,二氧化硫,溶剂黄146,Copper(L) Chloride体系中,用 水 作为反应溶剂,化学反应 1.83H,反应生成 3-乙酰基苯磺酰氯
参考文献: Lox Enzyme Inhibiting Methods And Compositions[fr] Procédés Et Compositions D'Inhibition De L'Enzyme Lox
标题: Lox Enzyme Inhibiting Methods And Compositions[fr] Procédés Et Compositions D'Inhibition De L'Enzyme Lox
摘要:这项发明涉及化合物,药物组合物及其用于治疗纤维化疾病,增殖性疾病,心血管疾病,急性和慢性炎症性疾病,原发性和转移性癌症,肺部疾病,眼部疾病或神经系统和神经精神疾病的用途.发明的一个特定方面涉及赖氨酸氧化酶酶家族的抑制剂及其作为治疗纤维化疾病的药物.

专利信息

专利号:US-8163773-B2
优先权日:2005-07-11
标题 :Organic compounds
发明人：BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.