2-(4-Bromophenyl)-2-(Trimethylsilyloxy)Acetonitrile置于盐酸体系中,化学反应 5.0H,反应生成 对溴扁桃酸 参考文献:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236 标题:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236
专利号:US-10975096-B2 优先权日:2014-06-20 标题 :Synthesis of polycyclic-carbamoylpyridone compounds 发明人:CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W 权利人:GILEAD SCIENCES INC 摘要:Methods of making compounds of Formula I are disclosed:
专利号:US-8138272-B2 优先权日:2006-05-22 标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds 发明人:KONRADI ANDREI W; SMITH JENIFER L 权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC 摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:EP-3527573-B1 优先权日:2014-06-20 标题:Synthesis of polycyclic-carbamoylpyridone compounds
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:CN-113355367-B 优先权日:2018-03-22 标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid
参考标题:Pd‐catalyzed Synthesis Of Vinyl Arenes From Aryl Halides And Acrylic Acid 作者:Yang Gao,Yang Ou,Lukas J. Gooßen 摘要:Reaction Of Acrylic Acid, Immediately Followed By Protodecarboxylation Of The Cinnamic Acid Intermediate. The Use Of The Carboxylate Group As A Deciduous Directing Group Ensures High Selectivity For Monoarylated Products. The Vinylation Process Is Generally Applicable To Diversely Substituted Substrates. Its Utility Is Shown By The Synthesis Of Drug‐like Molecules And The Gram‐scale Preparation Of Key Intermediates
合成参考文献
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