CAS: 6940-50-7; 4-Bromomandelicacid

该化合物是一种芳香化合物,其特点是存在溴原子和附于甲酸结构的碳酸酸性功能组,通常看起来像一种白色的离白晶体固体,4-溴二苯酸的分子式为C9H9BrO3,表明存在9个碳原子,9个氢原子,1个溴原子和3个氧原子.该化合物以其在有机合成和医药化学中的潜在应用而著称,特别是在药物的开发中.它显示了碳酸的典型特性,例如酸性和形成盐类和酯类的能力.溴基子分解可影响化合物的再活动性和生物活动,使其成为各种化学研究领域感兴趣的一个主题.此外,4-溴二苯醚可以参与各种化学反应,包括核糖替代和混合反应,这些在合成有机化学中是有价值的.

结构式图片

欧盟法规

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CAS号99-90-1 4-溴苯乙酮 | CAS号7716-86-1 1-(4-bromopheny... | CAS号1122-91-4 对溴苯甲醛 | CAS号3240-34-4 碘苯二乙酸 | CAS号14062-25-0 对溴苯乙酸乙酯 | CAS号83575-55-7 α-[(trimethylsi... | CAS号134219-51-5 N-(1-(4-bromoph... | CAS号1122-91-4 对溴苯甲醛 | CAS号1878-68-8 对溴苯乙酸 | CAS号7099-87-8 2-(4-溴苯基)-2-氧代乙酸 | CAS号450-52-2 a-羟基-[1,1-联苯]-4-乙酸

合成工艺路线路线简述

    2-(4-Bromophenyl)-2-(Trimethylsilyloxy)Acetonitrile置于盐酸体系中,化学反应 5.0H,反应生成 对溴扁桃酸
    参考文献:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236
    标题:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236

    海关参考信息

    专利信息


    专利号:US-10975096-B2
    优先权日:2014-06-20
    标题 :Synthesis of polycyclic-carbamoylpyridone compounds
    发明人:CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
    权利人:GILEAD SCIENCES INC
    摘要:Methods of making compounds of Formula I are disclosed:

    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:EP-3527573-B1
    优先权日:2014-06-20
    标题:Synthesis of polycyclic-carbamoylpyridone compounds

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:CN-113355367-B
    优先权日:2018-03-22
    标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid
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    主要参考文献

    参考标题:Pd‐catalyzed Synthesis Of Vinyl Arenes From Aryl Halides And Acrylic Acid
    作者:Yang Gao,Yang Ou,Lukas J. Gooßen
    摘要:Reaction Of Acrylic Acid, Immediately Followed By Protodecarboxylation Of The Cinnamic Acid Intermediate. The Use Of The Carboxylate Group As A Deciduous Directing Group Ensures High Selectivity For Monoarylated Products. The Vinylation Process Is Generally Applicable To Diversely Substituted Substrates. Its Utility Is Shown By The Synthesis Of Drug‐like Molecules And The Gram‐scale Preparation Of Key Intermediates

    合成参考文献


    摘要:Dornan, L. M.; Hughes, N. L.; Muldoon, M. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 559.
    摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 403.
    摘要:J. J. Klingenberg, J. P. Thole and R. D. Lingg, J. Chem. Eng. Data 11, 94 (1966).
    摘要:I. P. Alimarin and S. Hanshi, Russ. J. Inorg. Chem. (Engl. Transl.) 6, 1054 (1961).
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