CAS: 69-23-8; Fluphenazine
- 英文名称Fluphenazine
- 中文名称氟奋乃静
- IUPAC名称2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
- 其它别名1-Piperazineethanol,4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]- (6CI,7CI,8CI); 1-(2-Hydroxyethyl)-4-[3-(trifluoromethyl-10-phenothiazinyl)propyl]piperazine; 10-[3-(2-Hydroxyethyl)piperazinopropyl]-2-(trifluoromethyl)phenothiazine; 4-[3-(2-Trifluoromethyl-10-phenothiazyl)-propyl]-1-piperazineethanol; 4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazine ethanol; Elinol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazine; Ftorphenazine; Pacinol; Phthorphenazine; S 94; Siqualine; Siqualon; Triflumethazine; Vespazine
- CAS编号69-23-8
- MFCD编号:MFCD00242759
- EINECS号:200-702-9
- 分子式:C22H26F3N3OS分子量:437.52
- 产品CID: 1687814
- 同类组份化合物CAS69-23-8 (free base)146-56-5 (HCl)3093-66-1 (dimaleate)
- 产品分类原料药 → 神经系统用药 → 抗精神病药
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06 & GHS05;
注释: Skull and crossbones & Corrosion - 危险类别急性毒性 类别2(吸入)
急性毒性 类别3(经口)
皮肤腐蚀/刺激 类别2
严重眼损伤 类别1 - 警示词Danger(危险)
- 危险描述H330 |吸入致命.
H301 |吞咽会中毒.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤. - 防范说明P210-P260-P280-P301+P310-P311-P264-P270-P301+P310a-P321-P405-P501a
- 危险等级6.1
- UN编号UN1230 - class 3 - PG 2 - Methanol, solution
- 危险品标志F,T
- 安全声明16-36/37-45
- 危险类别码11-23/24/25-39/23/24/25
- WGK Germany1
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
oxirane SQ 10018 1-(2-hydroxyethyl)piperazine 10-(3-chloropropyl)-2-trifluoromethylphenothiazine1-(2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl)-pyridinium; toluene-4-sulfonate adamantane-1-carboxylic acid 2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethyl ester 1-hexanoyloxy-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethane -piperazin-ethylacetat-(1)4-3-(2-Trifluormethyl-phenothiazinyl-(10))-propyl-piperazin-ethylacetat-(1)合成工艺路线路线简述
📜1-甲酰基-4-(3-氯丙基)哌嗪 以 甲醇 作为反应溶剂,化学反应 1.0H,反应生成 氟奋乃静
参考文献:Anderson,Arzneimittel-Forschung/drug Research,1962,Vol. 12,P. 937-942
标题:Anderson,Arzneimittel-Forschung/drug Research,1962,Vol. 12,P. 937-942
海关参考信息
- 2902300000-甲苯
2921211000-乙二胺
2922110001-单乙醇胺
2922192100-二甲氨基乙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Xu F, Xia Y, Feng Z, Lin W, Xue Q, Jiang J, Yu X, Peng C, Luo M, Yang Y, Wei Y, Yu L. Repositioning antipsychotic fluphenazine hydrochloride for treating triple negative breast cancer with brain metastases and lung metastases. Am J Cancer Res. 2019 Mar 1;9(3):459-478. eCollection 2019.
2: Menilli L, García-Argáez AN, Dalla Via L, Miolo G. The neuroleptic drug fluphenazine induces a significant UVA-mediated cytotoxic effect on three human cancer cell lines through apoptosis. Photochem Photobiol Sci. 2019 Mar 12. doi: 10.1039/c9pp00023b. [Epub ahead of print] doi: 10.1007/s40199-018-0206-4. Epub 2018 Jul 24.
4: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK500732/ doi: 10.1002/14651858.CD006352.pub3. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK459194/ doi: 10.1007/s00044-017-1944-4. Epub 2017 Jun 15.
合成参考文献
合成方法参考DOI号:10.1002/jps.2600670209
📝 需求与反馈
尽可能描述清楚需求与问题信息
