专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:US-9181292-B2 优先权日:2011-01-05 标题 :Methods for preparation of glycosphingolipids and uses thereof 发明人:LIANG PI-HUI 权利人:LIANG PI-HUI 摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
专利号:WO-0026190-A1 优先权日:1998-10-30 标 题:Chiral amino alcohol derivatives of pyridine, a method for the manufacture thereof and their use as catalysts 发明人:NEVALAINEN VESA; SYLVESTRE DEGNI 权利人:NESTE CHEMICALS OY; NEVALAINEN VESA; SYLVESTRE DEGNI 摘要:The invention relates to chiral amino alcohol derivatives of pyridine, which compounds are useful as catalysts in combination with organic zinc compounds for asymmetric induction reactions and more particularly for enantioselective synthesis of optically active alcohols from aldehydes. The invention also relates to a process for the preparation of the said amino alcohol derivatives of pyridine and to a method for the manufacture of optically active alcohols from aldehydes in the presence of organic zinc compounds and amino alcohol derivatives of pyridine.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:WO-9811438-A1 优先权日:1996-09-13 标题 :Synthesis of quinazolinone libraries and derivatives thereof
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