CAS: 6160-78-7; 4-Methyl-7-(((2S,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2H-Chromen-2-One

相似化合物

28541-83-5 18997-57-4 6734-33-4

上下游产品

CAS号6160-79-8 4-Methylumbelli... | CAS号90-33-5 4-甲基伞形酮 | CAS号3947-62-4 2,3,4,6-四-O-乙酰基... | CAS号281207-18-9 propane-1,3-diy... | CAS号25878-60-8 1,2,3,4,6-D-葡萄糖五乙酸酯 | CAS号74808-10-9 2,3,4,6-四邻乙酰基-a... | CAS号3068-32-4 2,3,4,6-四乙酰氧基-a... | CAS号2956-16-3 UDP-GAL(UDP-半乳糖) | CAS号90-33-5 4-甲基伞形酮 | CAS号7296-64-2 β-D-半乳糖

4-甲基伞形酮2,3,4,6-四-O-乙酰基-Beta-D-吡喃半乳糖苷置于甲醇,Sodium Methylate体系中,化学反应 0.5H,以64%的收率获得产物4-甲基-7-乙酰氧基香豆素-β-D-吡喃半乳糖苷
参考文献:糖基香豆素碳酸酐酶ix和xii抑制剂可强烈减弱原发性乳腺肿瘤的生长.
标题:糖基香豆素碳酸酐酶ix和xii抑制剂可强烈减弱原发性乳腺肿瘤的生长.
摘要:合成了一系列结合了各种糖基部分的7-取代香豆素,并研究了其对锌酶碳酸酐酶的抑制作用(ca,Ec 4.2.1.1).这些香豆素作为管家抑制剂,脱靶亚型ca I和ii非常弱或无效,但其中一些在低纳摩尔范围内抑制与肿瘤相关的ca Ix和xii.它们还以30 Mg / Kg的高侵袭性4T1同系小鼠乳腺肿瘤细胞显着抑制了原发性肿瘤的生长,构成了开发概念上新颖的抗癌药物的有趣候选物.由于ca Ix在低氧性肿瘤中过表达,并且在正常组织中的表达非常有限,因此此类化合物可用于治疗对经典化学疗法和放射疗法无反应的癌症.
DOI:10.1021/jm200983E

专利信息

专利号:US-6479549-B2
优先权日:2000-02-28
标 题:Carnosic acid derivatives for promoting synthesis of nerve growth factor
发明人：KOSAKA KUNIO; MIYAZAKI TOSHITSUGU; YOKOI TOSHIO
权利人:NAGASE & CO LTD
摘要:A novel carnosic acid derivative for promoting the synthesis of nerve growth factor (NGF), a composition comprising the carnosic acid derivative as an effective ingredient, as well as, a method of promoting the synthesis of NGF comprising administering an effective amount of the carnosic acid derivative as an effective ingredient to a subject requiring such promotion. The carnosic acid derivative, composition and method according to the present invention can safely and efficiently promote the production of NGF in the living body, without being accompanied by a side effect such as a loss of a quantitative balance of hormones in the living body.

专利号:US-6391344-B2
优先权日:1999-12-02
标题:Method of promoting synthesis of nerve growth factor
发明人：KOSAKA KUNIO; MIYAZAKI TOSHITSUGU; ITO HISATOMI
权利人:NAGASE & CO LTD
摘要:A method of promoting the synthesis of nerve growth factor comprising administering an effective amount of rosemary and/or sage extracts or carnosic acid and/or carnosol as an effective ingredient to a subject requiring such promotion. The present method can safely and efficiently promote the production of NGF in the living body, without being accompanied by a side effect such as a loss of a quantitative balance of hormones in the living body.

专利号:US-5232829-A
优先权日:1989-09-29
标 题 :Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
发明人：LONGIARU MATHEW; SILVER SHERYL B; SULZINSKI MICHAEL A
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to the synthesis of amplified biotin-labelled DNA target sequences of Chlamydia trachomatis by polymerase chain reaction techniques and the detection of such sequences by a microtiter plate having plurality of wells and having bound thereto oligonucleotide capture probe complementary to said target sequence.

专利号:US-4959323-A
优先权日:1985-11-04
标 题:Production and use of pre S polypeptides of hepatitis B virus
发明人：ACS GEORGE; CHRISTMAN JUDITH K; PRICE PETER; OFFENSPERGER WOLF; WAHL SILKE
权利人:SINAI SCHOOL MEDICINE
摘要:In accordance with the present invention, recombinant plasmids are described which, when inserted into microbial hosts, direct the synthesis of proteins in which preS polypeptides found on the surface of human hepatitis B virus are fused to the enzyme beta -galactosidase. The recombinant plasmids are produced by inserting DNA sequences encoding the preS polypeptides into the lacZ gene, which codes for E. coli beta -galactosidase, carried by the plasmids. Large amounts of the preS- beta -galactosidase fusion proteins can be isolated from microbial cultures carrying the recombinant plasmids. Antigenic determinants of fusion protein so produced are recognized by antibodies to the preS determinants of native hepatitis B virus. The beta -galactosidase activity of such fusion protein is detected by a suitable chromogenic or fluorogenic substrate. PreS- beta -galactosidase fusion proteins so produced can be used in an enzyme-linked immunosorbent assay (ELISA) to diagnose the presence of hepatitis B virus infection. Additionally, the fusion proteins can be cleaved to release preS polypeptides which can be further purified. PreS polypeptides obtained from these fusion proteins can be used to immunize patients against hepatitis B virus.

专利号:US-5362625-A
优先权日:1991-05-15
标 题:Methods and compositions for enzyme complementation assays using the omega region of β-galactosidase
发明人：KREVOLIN MARK; KATES DAVID
权利人:MICROGENICS CORP
摘要:The use of omega-acceptor and omega-donor polypeptides (comprising about two-thirds and one-third of the beta -galactosidase molecule amino and carboxyl termini, respectively), prepared by recombinant DNA techniques, DNA synthesis, or chemical polypeptide synthesis techniques, which are capable of interacting to form an active enzyme complex having catalytic activity characteristic of beta -galactosidase, is described along with improved methods and novel compositions for enzyme complementation assays for qualitative and quantitative determination of a suspected analyte in a sample.

专利号:US-12012383-B2
优先权日:2018-03-26
标题 :Compositions and methods for inhibiting dihydroorotate dehydrogenase
发明人：KUMAR VIKRAM S; HESSON DAVID P; HUANG PING; JIA MO; YOU XIANJUN
权利人:CLEAR CREEK BIO INC
摘要:The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2′-halo-1-1′-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.