CAS: 574-84-5; 7,8-Dihydroxy-6-Methoxy-2H-Chromen-2-One

该化合物是一种自然形成的化合物,被归类为科马林衍生物,主要来自Fraxinos物种的树皮,通常称为灰树,其特点是芳香特性,以潜在的生物活动闻名,包括抗氧化剂,抗炎和抗微生物效应.Fraxetin展示了一种酚木结构,有助于其再活动以及与各种生物系统的互动.从溶解性角度讲,它一般是有机溶剂溶解的,但水溶性有限.该化合物由于其潜在的治疗用途,特别是在传统医学方面,已引起对药剂研究的兴趣.此外,Fraxetin在植物防护机制中的作用及其在环境中的生态意义是正在进行的研究领域.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号73815-12-0 fraxetin diacetate | CAS号4055-69-0 2,3-二羟基-4-甲氧基苯甲醛 | CAS号71765-80-5 6-Methoxy-7-(3-... | CAS号77369-04-1 obtusicin | CAS号667876-16-6 2,3-di[(isoprop... | CAS号2103-57-3 2,3,4-三甲氧基苯甲醛 | CAS号24778-11-8 7-β-D-glucopyra... | CAS号89019-07-8 8-乙酰基-7-甲氧基香豆素 | CAS号486-21-5 异秦皮啶 | CAS号525-21-3 嗪皮啶 | CAS号28843-40-5 7,8-亚甲基二氧基-6-甲氧基香豆素 | CAS号6035-49-0 白蜡树素 | CAS号114371-80-1 6,7,8-trihydrox... | CAS号84575-10-0 臭矢菜素C

合成工艺路线路线简述

  • 合成目标产物 7,8-Dihydroxy-6-Methoxycoumarin 主要起始原料 Scopoletin
  • (文献来源)合成步骤主要原料 Scopoletin
📜东莨菪内酯置于sodium Hydroxide,双氧水,溶剂黄146体系中,化学反应生成 秦皮素
参考文献:Spaeth; Schmid,Chemische Berichte,1941,Vol. 74,P. 595,598
标题:Spaeth; Schmid,Chemische Berichte,1941,Vol. 74,P. 595,598

海关参考信息

专利信息


专利号:US-11273138-B2
优先权日:2017-11-02
标 题 :Use of amino acid supplementation for improved muscle protein synthesis
发明人:WOLFE ROBERT R; FERRANDO ARNY
权利人:BIOVENTURES LLC
摘要:The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.

专利号:WO-2023156270-A1
优先权日:2022-02-18
标题:Coumarin synthesis and uses thereof
发明人:CONRATH UWE; LANGENBACH CASPAR; BEYER SEBASTIAN FELIX; SCHWINGES PATRICK; SCHULTHEISS HOLGER; BEESLEY ALEXANDER; LINKE CEDRIC
权利人:BASF SE; RWTH AACHEN
摘要:The present invention relates to genes, materials and methods for coumarin synthesis and the application thereof for improving plant health, preferably against infection by phythopathogenic microorganisms, and/or for improving plant health against coumarin-induced adverse effects on plant health. Furthermore, the invention pertains to methods and uses of such genes and mate- rials for creating correspondingly beneficial plant cells, plant parts and whole plants, and relates to products obtained from such plants or plant parts.

专利号:US-2025017211-A1
优先权日:2021-03-01
标题 :Solid particulate pest control compositions and methods
发明人:RODRIGUEZ IAN; ROSS DOUGLAS H; REED JANIS; PATTERSON HEATHER ERSKINE; KNOX MARIE; CARESPODI JOHN
权利人:CONTROL SOLUTIONS INC
摘要:Compositions and methods for controlling pests are disclosed. The compositions comprise a solid particulate chitin synthesis inhibitor and methods of using the chitin synthesis inhibitor to control a target pest. The chitin synthesis inhibitor is active in its solid form, and provides control of current and future pest generations independent of application timing with respect to insect life stage.

专利号:WO-2024223532-A1
优先权日:2023-04-28
标 题:A dietary supplement combination and use thereof for improving muscle performance
发明人:KASRAEE BEHROOZ
权利人:KASRAEE BEHROOZ
摘要:The present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis, muscle mass and strength. In particular, disclosed are compositions and methods of using the same for the prevention and / or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, for human, and especially adult or animals such as mammals.

专利号:US-2020253908-A1
优先权日:2017-11-02
标题 :Use of amino acid supplementation for improved muscle protein synthesis

专利号:EP-3703516-A1
优先权日:2017-11-02
标 题 :Use of amino acid supplementation for improved muscle protein synthesis

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献


1: Xia YL, Liang SC, Zhu LL, Ge GB, He GY, Ning J, Lv X, Ma XC, Yang L, Yang SL. Identification and characterization of human UDP-glucuronosyltransferases responsible for the glucuronidation of fraxetin. Drug Metab Pharmacokinet. 2014;29(2):135-40. Epub 2013 Sep 10.

合成参考文献


参考文献:10.1007/bf01192867
摘要:Yanishlieva NV, Marinova EM. Antioxidative effectiveness of some natural antioxidants in sunflower oil. Z Lebensm Unters Forsch. 1996 Sep;203(3):220–3. doi: 10.1007/bf01192867.
参考文献:10.1007/s12291-016-0564-y
摘要:Keshk WA, Katary MA. Transforming Growth Factor-β1/Smad3 Signaling and Redox Status in Experimentally Induced Nephrotoxicity: Impact of Carnosine. Indian Journal of Clinical Biochemistry. 2016 Apr 05;32(1):19–25. doi: 10.1007/s12291-016-0564-y.
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