CAS: 56121-42-7; (S)-2-((S)-2-Benzamido-3-Phenylpropanamido)-3-Phenylpropyl Acetate

上下游产品

N-(N-benzoyl-L-phenylalanyl)-L-phenylalaninol acetic anhydride benzoyl chloride Acetic acid (S)-2-((S)-2-amino-3-phenyl-propionylamino)-3-phenyl-propyl ester; compound with trifluoro-acetic acidN-(N-benzoyl-L-phenylalanyl)-L-phenylalaninol DL-N-benzoylphenylalanine

📜N-T-Boc-L-Phe-L-Phenylalaninol置于三乙胺,三氟乙酸体系中,用 吡啶,二氯甲烷 作为反应溶剂,化学反应生成 灰绿曲霉酰胺
参考文献:金色酰胺醇酯及其氟化衍生物及制备方法和应用
标题:金色酰胺醇酯及其氟化衍生物及制备方法和应用
摘要:本发明属于医药技术领域,公开了金色酰胺醇酯及其氟化衍生物及制备方法和应用.通式如下所示的金色酰胺醇酯,金色酰胺醇酯氟化衍生物或金色酰胺醇酯及其氟化衍生物药学上可接受的盐:其中,R1表示oh,Ch2Oh或ococh3;r2,R3和r4分別独立表示h,烷基或f.该金色酰胺醇酯及其氟化衍生物或药学上可接受的盐对预防或治疗流感病毒,特别是甲型流感病毒引起的感染具有很好的效果.对金色酰胺醇酯进行氟化改造使金色酰胺醇酯的生物活性更强.该金色酰胺醇酯及其氟化衍生物作用靶标既针对病毒,也针对宿主细胞,故不易产生耐药.

专利信息

专利号:US-9353112-B2
优先权日:2012-03-07
标 题 :Synthesis of polycyclic alkaloids
发明人：GOFF DANE; PAYAN DONALD G; BRASELMANN SYLVIA
权利人:RIGEL PHARMACEUTICALS INC
摘要:Disclosed embodiments concern polycyclic alkaloid compounds and methods for their use and synthesis. Particular embodiments concern polycyclic alkaloids having a fused, six-membered ring, while other embodiments concern polycyclic alkaloids having a fused, five-membered ring. Methods for making the polycyclic alkaloids are disclosed, as well as methods for their use as prophylactics or treatments for certain diseases. Also disclosed are pharmaceutical compositions comprising the polycyclic alkaloids and their use.

专利号:US-8524740-B2
优先权日:2010-07-15
标 题 :Synthesis and anticancer activity of aryl and heteroaryl-quinolin derivatives
发明人：KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG
权利人:KUO SHENG-CHU; LEE KUO-HSIUNG; HUANG LI-JIAU; CHOU LI-CHEN; WU TIAN-SHUNG; WAY TZONG-DER; CHUNG JING-GUNG; YANG JAI-SING; HUANG CHI-HUNG; TSAI MENG-TUNG; TAIRX INC
摘要:A compound of Formula I is disclosed as follows: n n n n n n n n n n n n or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein n R is hydrogen, P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , P(â•?O)(OH)(OM), P(â•?O)(OM) 2 , Pâ•?O(O 2 M), S(â•?O)(OH) 2 , S(â•?O)(O(C 1 -C 18 )alkylene(C 6 -C 20 )aryl) 2 , S(â•?O)(OH)(OM), S(â•?O)(OM) 2 ; n M is a monovalent or divalent metal ion, or alkylammonium ion; n W is (C 6 -C 20 )aryl, (C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkyl(C 6 -C 20 )aryl, (C 1 -C 18 )alkyl(C 6 -C 20 )heteroaryl, hydroxy(C 6 -C 20 )aryl, hydroxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkoxy(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )aryl, (C 1 -C 18 )alkylenedioxy(C 6 -C 20 )heteroaryl, halo(C 6 -C 20 )aryl, halo(C 6 -C 20 )heteroaryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )aryl, (C 1 -C 18 )alkylamino(C 6 -C 20 )heteroaryl, (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )aryl, or (C 1 -C 18 )cycloalkylamino(C 6 -C 20 )heteroaryl, and their OR 8 substutes; n R 5 is (C 1 -C 18 alkoxy, hydrogen, hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , or R 5 and R 6 are (C 1 -C 18 )dioxy provided that R 7 is hydrogen; n R 6 is hydroxyl, O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl, halo or OR 8 , (C 1 -C 18 )alkoxy, (C 1 -C 18 )alkylamino, or (C 1 -C 18 )cycloalkylamino, or R 6 and R 7 are (C 1 -C 18 )dioxy provided that R 5 is hydrogen; n R 7 is hydrogen, halo or OR 8 , hydroxyl, or O—(C 1 -C 18 )alkyl(C 6 -C 20 )aryl; and n R 8 is P(â•?O)(OH) 2 , P(â•?O)(O(C 1 -C 18 )alkyl(C 6 -C 20 )aryl) 2 , Pâ•?O)(OH)(OM), or P(â•?O)(OM) 2 , Pâ•?O(O 2 M).

专利号:EP-0674008-A1
优先权日:1989-08-30
标 题:Preparation of optically active cyclohexenol and cyclohexenyl acetic acid via an enzymatic process followed by a rearrangement reaction and their use as intermediates in the synthesis of indolobenzoquinoline derivatives

专利号:US-8927564-B2
优先权日:2012-03-07
标题:Synthesis of polycyclic alkaloids

专利号:US-2015087633-A1
优先权日:2012-03-07
标题 :Synthesis of polycyclic alkaloids

专利号:ES-2773838-T3
优先权日:2012-03-07
标 题:Synthesis of polycyclic alkaloids and their use as TGR5 agonists