CAS: 55566-30-8; Tetrakis(Hydroxymethyl)Phosphonium (Sulfate)

专利信息

专利号:US-8314090-B2
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives
发明人：HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON
权利人:HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON; VENTIRX PHARMACEUTICALS INC; ARRAY BIOPHARMA INC
摘要:The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

专利号:WO-2017166916-A1
优先权日:2016-04-01
标题:Tetrakis(4-hydroxyphenylaminomethyl)phosphonium sulfate and synthesis method thereof
发明人：DAI LIZONG; LIU CHAO; HUANG JIAMEI; CHEN GUORONG; YUAN CONGHUI; LUO WEI'ANG
权利人:UNIV XIAMEN
摘要:The present invention synthesizes tetrakis(4-hydroxyphenylaminomethyl) phosphonium sulfate having a structural formula of (I), and describes a synthesis method thereof. The raw material comprises tetrakis-hydroxymethyl phosphonium sulfate (THPS), p-aminophenol, an organic solvent, and distilled water. The synthesis method comprises: reacting, in an organic solvent, THPS with p-aminophenol; performing vacuum filtration at reduced pressure, washing, and purifying; and finally, removing the solvent to obtain the phosphonium sulfate of the present invention.

专利号:US-10968173-B2
优先权日:2016-07-07
标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization
发明人：COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN
权利人:UNIV IOWA STATE RES FOUND INC
摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.

专利号:ES-2705101-T3
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives

专利号:CA-2742863-C
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives

专利号:AU-2009313392-B2
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives