CAS: 51115-67-4; 2-Isopropyl-N,2,3-Trimethylbutanamide

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299-78-5 51115-70-9 55265-53-7

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CAS号55897-64-8 2-异丙基-2,3-二甲基丁腈 | CAS号616-38-6 碳酸二甲酯 | CAS号67-56-1 甲醇 | CAS号75-93-4 methyl hydrogen...

3-Isopropyl-3,4-Dimethyl-Pentan-2-One置于盐酸羟胺,Potassium Carbonate体系中,用 四氢呋喃 作为反应溶剂,化学反应 2.0H,以49.7%的收率获得产物n,2,3-三甲基-2-异丙基丁酰胺
参考文献:一种凉味剂n,2,3-三甲基-2-异丙基丁酰胺的合成方法
标题:一种凉味剂n,2,3-三甲基-2-异丙基丁酰胺的合成方法
摘要:本发明公开了一种凉味剂n,2,3‑三甲基‑2‑异丙基丁酰胺的合成方法,包括如下步骤:(1)乙酰乙酸甲酯在强碱条件下与2‑溴丙烷反应得到3,3‑二异丙基乙酰乙酸甲酯;(2)将得到的3,3‑二异丙基乙酰乙酸甲酯与乙二醇反应使酮羰基得到保护,然后在还原剂的作用下将酯水解成羟基,再与对甲基苯磺酰氯反应,然后脱除对基苯磺酸酯,而得到3‑异丙基‑4‑甲基‑2‑戊酮;(3)将3‑异丙基‑4‑甲基‑2‑戊酮与盐酸羟胺反应,然后在酸条件下经贝克曼重排而得到n,2,3‑三甲基‑2‑异丙基丁酰胺.该方法通过酯基甲基化与贝克曼重排而成功得到了n,2,3‑三甲基‑2‑异丙基丁酰胺,为合成ws‑3提供了一种新的合成方法,且该方法收率较高,适合大规模生产.

专利信息

专利号:US-2018312463-A1
优先权日:2015-10-22
标题:Synthesis of Cyclohexane Carboxamide Derivatives Useful as Sensates in Consumer Products
发明人：YELM KENNETH EDWARD; WOS JOHN AUGUST; BUNKE GREGORY MARK; FREDERICK HEATH; HAUGHT JOHN CHRISTIAN; HOKE STEVEN HAMILTON; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

专利号:US-2022288005-A1
优先权日:2019-07-26
标题:Synthesis of pro-resolving analogs and compositions therefor
发明人：VAN DYKE THOMAS E; SERHAN CHARLES N
权利人:NOCENDRA INC
摘要:This disclosure relates to methods of synthesizing certain lipoxin analogs (e.g., lipoxin mimetics, etc.) and pharmaceutical compositions comprising these pro-resolving compounds. Methods of administering the lipoxin mimetics (e.g., lipoxin A4 mimetics, lipoxin B4 mimetics, etc.) to patients in need thereof are also provided.

专利号:US-2019276389-A1
优先权日:2015-12-18
标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
发明人：WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

专利号:US-8754259-B2
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
发明人：YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

专利号:WO-2017070418-A1
优先权日:2015-10-22
标 题:Synthesis of cyclohexane carboxamide derivatives useful as sensates in consumer products

专利号:CA-2731967-A1
优先权日:2008-08-15
标 题:Synthesis of cyclohexane derivatives useful as sensates in consumer products