CAS: 465-39-4; 5-((1R,2Ar,3As,3Br,5Ar,7S,9As,9Bs,11Ar)-7-Hydroxy-9A,11A-Dimethylhexadecahydronaphtho[1',2':6,7]Indeno[1,7A-B]Oxiren-1-yl)-2H-Pyran-2-One

上下游产品

3-Oxo-Resibufogenin 62859-80-7

在 吡啶,咪唑,甲醇,N-溴代丁二酰亚胺(Nbs),Wilkinson'S Catalyst,四(三苯基膦)钯,氯化亚砜,高氯酸,Copper Chloride Dihydrate,5%-Palladium/activated Carbon,氢气,碘,4-甲基苯磺酸吡啶,Potassium Carbonate,四丁基高碘酸铵,对甲苯磺酸,氟化氢吡啶,一水合肼,三乙胺体系中,用 四氢呋喃,1,4-二氧六环,甲醇,乙醇,二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 76.5H,反应生成 布福吉宁
参考文献:一种天然蟾毒基内酯类化合物的制备方法
标题:一种天然蟾毒基内酯类化合物的制备方法
摘要:本发明公开了一种天然蟾毒基内酯类化合物的制备方法,从廉价易得的商业甾体骨架原料,如雄烯二酮4‑ad或3β‑羟基‑5β‑雄甾烷‑17‑酮等出发,通过生物‑化学接力合成或者化学合成方法经过简单转化得到中间体3β,14α‑二羟基‑5β‑雄甾烷‑17‑酮类化合物,然后再通过化学半合成完成e环即六元二烯内酯环的上载,最终实现蟾毒基内酯类化合物的合成.该制备方法操作简单,收率较高,可用于大规模制备该类天然产物,具有广泛的应用前景.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-3682895-A
优先权日:1970-07-17
标题 :Synthesis of 3-hydroxy-5-bufa-20,22-dienolide
发明人：PETTIT GEORGE R; FESSIER DYRAL C; PAUIL KENNETH D
权利人:GEORGE R PETTIT; DYRAL C FESSIER; KENNETH D PAUIL
摘要:THERE IS PROVIDED A NOVEL METHOD OF SYNTHEESIZING 5ABUFADIENOLIDES, WHICH ARE USEFUL INTERMEDIATES IN THE TOTAL SYNTHESIS OF BUFALIN, A CARDIAC ACTIVE COMPOUND. EPIANDROSTERONE ACETATE IS CONVERTED INTO 3B - ACETOXYL-5APREGNANE-21-AL WHICH UNDERGOES CHAIN EXTENSION TO METHYL 3B-ACETOXYL-20-FORMYL-21-NOR-5A-CHOLANATE WHICH IS RING CLOSED TO FORM THE 3B - ACETOXY-5-A-BUF-20(21)-ENOLIDE WHICH IS DEHYDROGENATED TO THE CORRESPONDING BUFADIENOLIDE.

专利号:US-11130948-B2
优先权日:2013-03-15
标题 :Compositions and methods for multiplex nucleic acids synthesis
发明人：JACOBSON JOSEPH; SCHINDLER DANIEL; SAAEM ISHTIAQ E; LAWTON SCOTT S; GOLDBERG MARTIN J; HUDSON MICHAEL E; KUNG LI-YUN A
权利人:GEN9 INC
摘要:Aspects of the invention relate to methods, compositions for designing and producing a target nucleic acid. In particular, aspects of the invention relate to the multiplex synthesis of target polynucleotides.

专利号:US-10053719-B2
优先权日:2013-03-13
标题:Compositions and methods for synthesis of high fidelity oligonucleotides
发明人：SAAEM ISHTIAQ E; HUDSON MICHAEL E; ARCHER STEPHEN F; SANN-RORTH SOPHEA; SANCHEZ ELLEN J; JACOBSON JOSEPH
权利人:GEN9 INC
摘要:Aspects of the invention relate to methods, compositions for synthesizing high fidelity oligonucleotides.

专利号:US-7635462-B2
优先权日:2006-09-15
标题 :Method of making porous crystalline materials
发明人：CAO GUANG; SHAH MATU J
权利人:EXXONMOBIL RES & ENG CO
摘要:The present invention relates to new methods of making crystalline materials isostructural to ITQ-21, as well as to new crystalline materials obtainable by such methods, and their use in hydrocarbon conversion processes. In one of its aspects, the invention relates to a method of making a crystalline material iso-structural to ITQ-21, the method comprising:n (a) providing a synthesis mixture comprising water, at least one source of germanium, at least one source of a tetravalent element X other than germanium, at least one structure directing agent R, optionally at least one source of trivalent element Y and optionally at least one source of fluoride, wherein the structure directing agent R is a compound of formula C 1 C 2 R 1 R 2 N + A − (I),n in whichn C 1 and C 2 each independently represent a substituted or unsubstituted cyclohexyl or cyclopentyl group, R 1 and R 2 each independently represent a methyl group, an ethyl group or a propyl group, or R 1 and R 2 together with the nitrogen atom they are connected to form a ring containing 5 or 6 atoms, and A represents hydroxyl, fluorine, chlorine, bromine or iodine, n n (b) forming said crystalline material from the synthesis mixture; (c) recovering said crystalline material.

专利号:EP-0252846-A1
优先权日:1986-07-08
标 题 :Catalyst for the synthesis of methanol, and its use in the synthesis of methanol