CAS: 4360-63-8; 2-Bromomethyl-1,3-Dioxolane

相似化合物

20599-01-3 87227-41-6 5694-68-8

上下游产品

CAS号7252-83-7 溴代乙醛缩二甲醇 | CAS号107-21-1 乙二醇 | CAS号2032-35-1 2-溴-1,1-二乙氧基乙烷 | CAS号497-26-7 2-甲基-1,3-二氧戊环 | CAS号17157-48-1 溴乙醛 | CAS号6304-35-4 Ethane,1,1'-oxy... | CAS号108-05-4 乙酸乙烯酯 | CAS号57366-77-5 2-(甲胺基甲基)-1,3-二氧六环 | CAS号52509-14-5 (1,3-二氧环戊基-2-甲基... | CAS号764-48-7 2-乙烯氧基乙醇 | CAS号136117-69-6 咪唑并[1,2-a]吡啶-6-甲酸甲酯 | CAS号1606-75-3 (甲酰基甲基)磷酸二乙酯 | CAS号17053-09-7 二乙基(1,3-二氧戊环-2-... | CAS号115754-62-6 三丁基(1,3-二恶烷-2-基... | CAS号78950-65-9 1,3-dioxolan-2-... | CAS号898776-72-2 ethyl 3-(1,3-di...

2-甲基-1,3-二氧戊环置于di-Tert-Butyldicyclohexano-18-Crown-18 溴体系中,用 苯 作为反应溶剂,化学反应 0.17H,以96%的收率获得产物2-溴甲基-1,3-二氧戊烷
参考文献:Kotlyar; Pluzhnik-Gladyr',Russian Journal Of General Chemistry,1998,Vol. 68,# 6,P. 914-916
标题:Kotlyar; Pluzhnik-Gladyr',Russian Journal Of General Chemistry,1998,Vol. 68,# 6,P. 914-916

专利信息

专利号:EP-2231627-B1
优先权日:2007-12-03
标题 :New process for the synthesis of moguisteine
发明人：VIGANO' ENRICO; ARRIGHI MASSIMILIANO; MOLTENI RENATO; LANFRANCONI SIMONA; LANDONIO ERNESTO
权利人:A M S A ANONIMA MATERIE SINT E AFFINI S P A
摘要:The invention relates to a process for the synthesis of moguisteine that is ethyl ester of (R,S)-3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxypropanoic acid which comprises the steps of forming a new cyclic intermediate of formula 2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane (4), forming (R,S)-2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidine (6) and reacting this latter with monoethylmalonic acid (7) or a salt thereof. The moguisteine of the invention is obtained in high yield and purity.

专利号:US-6096874-A
优先权日:1990-10-01
标 题:High affinity tamoxifen derivatives
发明人：WALLACE SIDNEY; YANG DAVID; DELPASSAND EBRAHIM; CHERIF ABDALLAH; QUADRI SYED M
权利人:UNIV TEXAS
摘要:The synthesis of tamoxifen derivatives, most particularly halo, halo alkyl, hydroxy, and amino tamoxifen derivatives is disclosed. The native tamoxifen molecule includes a substituted chemical group positioned on the aliphatic chain of the tamoxifen molecule. Particular tamoxifen derivatives of the invention include chloro, bromo, iodo, fluoro, amino and DTPA tamoxifen derivatives, and corresponding lower alkyl halogenated forms. The halogenated tamoxifen derivatives possess superior binding affinities for estrogen receptor rich tissues, such as uterine tissue and breast tissue, relative to unsubstituted native tamoxifen. Radiolabeled forms of the tamoxifen derivatives may be used as highly specific imaging agents for estrogen receptor rich tissues. The fluoro and bromo tamoxifen derivatives are particularly useful for imaging estrogen receptors by PET whereas the iodinated tamoxifens are particularly useful in imaging estrogen receptors by SPECT. Rapid and efficient methods of preparing the tamoxifen derivatives having high specific activity (>6 Ci/μmol) are also disclosed. Aliphatic chain substituted tamoxifen derivatives are shown to possess greater estrogen receptor binding affinity and more potent tumor cell inhibition than tamoxifen or tamoxifen derivatives substituted at other locations on the molecule (i.e., non-aliphatic chain substituted tamoxifen). The tanioxifen derivatives of the present invention may advantageously be used as anti-cancer therapeutic agents to halt estrogen-receptor positive tumors, such as those of breast and uterine tissue. The present invention also provides a hydrophilic DTPA-tamnoxifen analogue, and uses thereof in imaging estrogen receptor positive ER+ lesions.

专利号:US-7858821-B2
优先权日:2007-11-13
标题 :Intermediate compounds useful to prepare dolasetron
发明人：ANDRES JUAN ANTONIO PEREZ; BARJOAN PERE DALMASES; CLOTET JOAN HUGUET
权利人:INKE SA
摘要:The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.

专利号:WO-2009071528-A2
优先权日:2007-12-03
标题 :New process for the synthesis of moguisteine

专利号:US-6586615-B1
优先权日:2001-01-10
标题:α-aminoboronic acids prepared by novel synthetic methods
发明人：KETTNER CHARLES A; JAGANNATHAN SHARADA; FORSYTH TIMOTHY PATRICK
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to a novel class of alpha-aminoboronic acids of Formula (V),which are useful as intermediates in synthetic processes for inhibitors of the serine proteases, leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin. More specifically, the alpha-aminoboronic acids are useful as intermediates for the synthesis of Hepatitis C Virus (HCV) protease inhibitors. This invention also generally relates to novel methods for the preparation of alpha-aminoboronic acids.

专利号:EP-1639121-A4
优先权日:2003-06-30
标题:SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES