CAS: 32852-81-6; 3-Phenoxyphenylacetic Acid

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CAS号53874-66-1 3-苯氧基苄氯 | CAS号109330-01-0 (3-苯氧基苯基)乙醛 | CAS号66644-22-2 ethyl (3-phenox... | CAS号51632-29-2 3-苯氧基苯乙腈 | CAS号39515-51-0 间苯氧基苯甲醛 | CAS号51632-16-7 间苯氧基溴化苄 | CAS号13826-35-2 3-苯氧基苄醇 | CAS号591-50-4 碘苯 | CAS号22446-38-4 (3-羟苯基)乙酸乙酯 | CAS号3586-14-9 3-苯氧基甲苯

📜2-(3-苯氧基苯基)乙酸甲酯置于sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,反应生成 3-苯氧基苯乙酸
参考文献:1-(1-Arylethylpiperidin-4-yl)Thymine 类似物作为抗分枝杆菌 Tmpk 抑制剂
标题:1-(1-Arylethylpiperidin-4-yl)Thymine 类似物作为抗分枝杆菌 Tmpk 抑制剂
摘要:合成了一系列基于报道的化合物 3 的结核分枝杆菌 Tmpk (Mtbtmpk) 抑制剂,并评估了它们抑制 Mtbtmpk 催化活性和强毒结核分枝杆菌菌株 (H37Rv) 生长的能力.对 3 支架的修饰未能显着改善 Mtbtmpk 抑制活性和抗分枝杆菌活性.3 的 D 环取代模式的优化导致化合物 21J 具有改善的 Mtbtmpk 抑制效力(三倍)和 H37Rv 生长抑制活性(两倍).将 21J 的 3-氯取代基移到对位得到异构体 21H,尽管 Ic50 值增加了 10 倍,但显示出有希望的全细胞活性(最小抑制浓度 (Mic) = 12.5 μm).
DOI:10.3390/molecules25122805

专利信息

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:US-2002045747-A1
优先权日:1996-12-23
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2002052359-A1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2002173504-A1
优先权日:1996-12-23
标题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2004043977-A1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds