专利号:US-10851130-B2 优先权日:2018-01-29 标题:Chemical synthesis method of Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide 发明人:YIN JIAN; HU JING; SEEBERGER PETER; QIN CHUNJUN 权利人:UNIV JIANGNAN; MAX PLANCK INST OF COLLOIDS AND INTERFACES 摘要:The present disclosure discloses the chemical synthesis method of the Plesiomonas shigelloides serotype O51 O-antigen oligosaccharide, belonging to the field of chemistry. Source-abundant D-glucose, L-fucose, D-glucosamine and the like are used as raw materials to prepare three glycosylation building blocks, the synthetic route composed of 11 reaction modules is designed, and through the optimization of protecting group and the optimization of the time of introducing functional group, the preparation of the target oligosaccharide chain is successfully achieved. The oligosaccharide chain prepared in the present disclosure has the advantages of cheap and easy-to-get raw materials, and simple and easy-to-repeat preparation method. The present disclosure will have good application prospects in the aspects of development of new drugs and vaccines of Plesiomonas shigelloides , and the like.
专利号:US-8697862-B2 优先权日:2008-05-16 标题 :Synthesis of galactoside inhibitors 发明人:NILSSON ULF 权利人:NILSSON ULF; GALECTO BIOTECH AB 摘要:Novel synthesis routes for preparation of thiodigalactosides and intermediates are presented. The method includes the use of a 3-azido-galactosyl thiouronium salt derivative, which is activated to the corresponding thiol in situ, which in turn is directly reacted with a 3-azido-galactosyl bromide resulting in the 3,3′-di-azido-thio-di-galactoside before the thiol has a chance to reduce the azido 10 group. Hence, in situ formation of the 3-azido-galactosyl thiol from the thiouronium salt is essential in the synthesis procedure, because any other method that generate the thiol separately results in extensive unwanted azide reduction.
专利号:US-2024409571-A1 优先权日:2023-06-08 标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines 发明人:CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN 权利人:UNIV CALIFORNIA 摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.
专利号:WO-2009139719-A9 优先权日:2008-05-16 标 题 :Novel synthesis of galactoside inhibitors
专利号:CA-2724064-C 优先权日:2008-05-16 标题 :Synthesis of galactoside inhibitors
专利号:WO-2018002957-A2 优先权日:2016-06-29 标题 :A method for synthesis of 6-deoxy-l-hexoses from l-rhamnose
参考标题:Copper-Catalyzed Synthesis Of Esters From Ketones. Alkyl Group As A Leaving Group 作者:Yuji Nakatani,Yuichiro Koizumi,Ryu Yamasaki,Shinichi Saito |发布日期:2008.5.1 摘要:The Conversion Of Ketones To Esters Has Been Achieved Through The Use Of Cu Catalyst And Tetrabutylammonium Nitrite. This Reaction Involves The Activation Of The Less Activated C-C Bond, And The Alkyl Group Is Removed As A Leaving Group. Various Isopropyl Ketones Are Found To Be Good Substrates For This Reaction.
合成参考文献
摘要:Chand, K.; Umesh; Dorairaj, D. P.; Hsu, S. C. N., Science of Synthesis Knowledge Updates, (2021) 2, 271.