CAS: 23564-05-8; Thiophanate-Methyl

异硫氰酰甲酸甲酯,邻苯二胺 以 丙酮,乙腈 用作溶剂,以99.6%的收率获得甲基硫菌灵
参考文献:甲基硫菌灵的合成方法
标题:甲基硫菌灵的合成方法
摘要:本发明属于农药合成技术领域,具体涉及一种甲基硫菌灵的合成方法.本发明提供的甲基硫菌灵的合成方法,将异硫氰基甲酸甲酯的丙酮溶液滴加至邻苯二胺的丙酮‑乙腈溶液中,保温反应,然后降温析晶,得到甲基硫菌灵晶体,少量异硫氰基甲酸甲酯与大量邻苯二胺接触,增加了异硫氰基甲酸甲酯与邻苯二胺的接触面积,避免了常规将邻苯二胺滴加至异硫氰基甲酸甲酯中分子接触不均匀的问题,使得反应过程更加可控,不会存在冲料现象;丙酮和乙腈为强极性溶剂,将邻苯二胺溶解在丙酮‑乙腈混合溶剂中,并控制丙酮和乙腈的体积比为100:(11~15),改善了邻苯二胺溶解度,增加了异硫氰基甲酸甲酯与邻苯二胺接触时间,反应更加完全,提高了产能.

专利信息

专利号:WO-2025056767-A1
优先权日:2023-09-15
标题 :Process for the preparation of enantiomerically enriched aliphatic amines
发明人：BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
权利人:SYNGENTA CROP PROTECTION AG
摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

专利号:US-2016073631-A1
优先权日:2013-03-04
标 题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:WO-2022061431-A1
优先权日:2020-09-23
标题 :Delta 24-sterol methyltransferase enzyme inhibitor metalloazasterol compound, pharmaceutical composition and use of the compound
发明人：GUILLERMO VISBAL SILVA GONZALO; COROMOTO NAVARRO ACOSTA MARIBEL; MANOEL DA SILVA JUSTO RODRIGO; COLA FERNANDES RODRIGUES JULIANY; TEIXEIRA DE MACEDO SILVA SARA; DE SOUZA WANDERLEY; DOS SANTOS DA SILVA GABRIELLE
权利人:INSTITUTO NAC DE METROLOGIA QUALIDADE E TECNOLOGIA INMETRO; UNIV FEDERAL DE JUIZ DE FORA UFJF; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:The present invention relates to a novel compound, dichlorobis(22-hydrazone-imidazoline-2-yl-chol-5-en-3-beta-ol)zinc(II), which consists of a metalloazasterol that results from complexing zinc with two 22-hydrazone-imidazoline-2-yl-chol-5-en-3-beta-ol (H3) molecules and selectively inhibits the enzyme delta 24-sterol methyltransferase (24-EMT), which is essential for the synthesis of ergosterol and other 24-alkylated sterols found in the membrane of parasites and fungi, therefore being particularly useful for treating parasitic diseases, such as leishmaniasis and Chagas disease, and fungal diseases. Other aspects of the present invention consist of a pharmaceutical composition comprising the novel compound and also use thereof.

专利号:US-9233920-B2
优先权日:2010-06-11
标题 :Process for the preparation of dihydropyrrole derivatives
发明人：EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

专利号:US-10906880-B2
优先权日:2016-01-26
标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
发明人：FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
权利人:UNIV NANKAI
摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

专利号:US-9968097-B2
优先权日:2012-05-30
标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction
发明人：WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.