CAS: 2292-16-2; 4-[[(1R)-6,7-Dimethoxy-2-Methyl-3,4-Dihydro-1H-Isoquinolin-1-Yl]Methyl]-2-[[(1R)-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-3,4-Dihydro-1H-Isoquinolin-7-Yl]Oxy]Phenol

上下游产品

(1R)-7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline (S)-1-(4-(benzyloxy)-3-bromobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

📜(R)-7-(Benzyloxy)-6-Methoxy-1-(4-Methoxybenzyl)-2-Methyl-1,2,3,4-Tetrahydroisoquinoline置于吡啶,Copper(I) Bromide Dimethylsulfide Complex,Palladium 10% On Activated Carbon,氢气,三氯化硼,Caesium Carbonate,溶剂黄146体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 28.0H,反应生成甲基莲心碱
参考文献:莲ne莲胚中生物碱的合成及药理活性
标题:莲ne莲胚中生物碱的合成及药理活性
摘要:立体选择性地合成了双苄基异喹啉生物碱,最近从睡莲的胚中分离出的睡莲碱和睡莲的立体异构体,其是睡莲胚的主要生物碱.评估了肾上腺素,肾上腺素的立体异构体,莲心碱,异莲心碱和o-甲基肾上腺素的药理活性.
Doi:10.1248/cpb.C12-00820

专利信息

专利号:US-12091696-B2
优先权日:2022-08-10
标 题 :O-methyltransferase protein with highly specific catalytic function for multiple bias parent nuclei and encoding gene and use thereof
发明人：CHEN SHA; YU YUETONG
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The present disclosure provides an O-methyltransferase protein with a highly specific catalytic function for multiple benzylisoquinoline alkaloids (BIAs) parent nuclei and an encoding gene and use thereof. Compared with wild-type O-methyltransferase, the O-methyltransferase protein (SEQ ID NO: 2) shows an enhanced enzymatic activity and a wider substrate scope. The O-methyltransferase protein can catalyze O-methylation of backbones from three BIAs, including monobenzylisoquinolines (norcoclaurine, coclaurine, and N-methylcoclaurine), aporphines (asimilobine and N-methylasimilobine), and protoberberines (scoulerine and tetrahydrocolumbamine). Meanwhile, this O-methyltransferase protein is highly regioselective for each backbone. The O-methyltransferase protein catalyzes methylation of the monobenzylisoquinolines at 6-OH and 7-OH, is only active on 6-OH of the backbone of the aporphines, and mainly catalyzes methylation of the protoberberines at 2-OH. Moreover, the O-methyltransferase protein has a stronger catalytic activity and can be used as a biocatalyst for the semi-synthesis of related compounds.

专利号:CN-113755552-A
优先权日:2021-04-15
标 题 :Synthesis method of chiral fused ring tetrahydroisoquinoline alkaloid and analogue thereof