CAS: 214360-73-3; 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Aniline

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CAS号106-40-1 对溴苯胺 | CAS号25015-63-8 频那醇硼烷 | CAS号540-37-4 对碘苯胺 | CAS号73183-34-3 双戊酰二硼 | CAS号171364-83-3 4-硝基苯硼酸频哪醇酯 | CAS号627093-70-3 6-methyl-1-oxo-... | CAS号864754-08-5 2,2,2-TRIFLUORO... | CAS号106-50-3 对苯二胺 | CAS号5419-55-6 硼酸三异丙酯 | CAS号5089-33-8 4-溴-N,N-双(三甲基甲硅烷基)苯胺 | CAS号1056016-74-0 2-氯-9-(1-甲基乙基)-... | CAS号5730-78-9 4'-氨基-4-联苯基羧酸 | CAS号39968-33-7 1-羟基-7-偶氮苯并三氮唑(HOAt) | CAS号880545-43-7 N-[4-(4,4,5,5-t... | CAS号330793-01-6 N-B°C-4-氨基苯硼酸频哪醇酯 | CAS号929203-04-3 4-(3-吡啶基)苯硼酸频哪醇酯 | CAS号380430-57-9 4-(甲基磺酰基氨基)苯硼酸 | CAS号443998-73-0 3-(4-氨基苯基)苯甲腈 | CAS号92-36-4 2-(4-氨基苯基)-6-甲基苯并噻唑 | CAS号540-37-4 对碘苯胺

6-Methyl-1-Oxo-2-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-yl)Phenyl]-1,2-Dihydrobenzo[b][1,6]Naphthyridine-4-Carboxylic Acid置于三乙胺体系中,用 Dmf (N,N-Dimethyl-Formamide),甲苯 用作溶剂,以45%的收率获得4-氨基苯硼酸频哪醇酯
参考文献: Anti-Tumour Polycyclic Carboxamides[fr] Carboxamides Polycycliques Anti-Tumorales
标题: Anti-Tumour Polycyclic Carboxamides[fr] Carboxamides Polycycliques Anti-Tumorales
摘要:本发明涉及具有细胞毒性的多环羧酰胺化合物的公式(i),其制备方法,含有它们的药物组合物以及它们在治疗中的应用,特别是在治疗和/或预防癌症等细胞增殖性疾病方面的应用.

专利信息

专利号:US-9745303-B2
优先权日:2012-10-12
标题:Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
发明人：HOWARD PHILIP WILSON
权利人:SPIROGEN SÀRL; MEDIMMUNE LTD
摘要:A method of synthesing a compound of formula (I) from a compound of formula (III).

专利号:US-9707301-B2
优先权日:2011-10-14
标题 :Pyrrolobenzodiazepines and targeted conjugates
发明人：JEFFREY SCOTT; BURKE PATRICK; HOWARD PHILIP WILSON
权利人:SEATTLE GENETICS INC; MEDIMMUNE LTD
摘要:This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-8785632-B2
优先权日:2004-08-26
标 题:Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
发明人：CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE
权利人:CUI JINGRONG JEAN; FUNK LEE ANDREW; JIA LEI; KUNG PEI-PEI; MENG JERRY JIALUN; NAMBU MITCHELL DAVID; PAIRISH MASON ALAN; SHEN HONG; TRAN-DUBE MICHELLE; AGOURON PHARMA; PFIZER
摘要:Enantiomerically pure compound of formula 1 n nare provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.