CAS: 21104-28-9; Mahanimbine
该化合物是主要来自Murraya koenigii 植物(俗称咖哩叶)的杂醇藻类,其特点是复杂的分子结构,其中包括一个典型的多种杂质衍生物的双环框架.Mahanimbine展示了一系列的生物活动,包括抗微生物,抗炎和潜在的抗癌特性,使其对药理研究感兴趣.该化合物以其与各种生物目标互动的能力而著称,这些生物目标可能有助于治疗效果.此外,还研究了其在传统医学中的作用,特别是在Ayurvedic习俗中的角色.Mahanimbine的溶性性和稳定性可以因环境条件而不同而有所变化,环境条件对于其在研究和潜在药剂配方的应用都很重要.与许多天然产品一样,需要进一步研究,以充分阐明其行动和潜在健康惠益的机制.
- 英文名称Mahanimbine
- 中文名称Mahanimbin; (+)-3,11-二氢-3,5-二甲基-3-(4-甲基-3-戊烯-1-基)吡喃并[3,2-a]咔唑
- IUPAC名称3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3,11-dihydropyrano[3,2-a]carbazole
- 其它别名Mahanimbine; Mahanimbin; (+)-3,11-Dihydro-3,5-Dimethyl-3-(4-Methyl-3-Penten-1-yl)Pyrano[3,2-A]Carbazole; Pyrano[3,2-A]Carbazole, 3,11-Dihydro-3,5-Dimethyl-3-(4-Methyl-3-Penten-1-yl)-, (3S)-; (+)-Mahanimbine; Mahanimbine-Rm
- CAS编号21104-28-9
- MFCD编号:MFCD32671744
- EINECS号:106-616-7
- 分子式:C23H25NO分子量:331.46
- 产品CID: 1091792
- 产品分类天然产物 → 生物碱
物理性质
- 熔点94-95 °C
- 沸点502.6±39.0 °C(预测)
- 闪点178.3 °C
- 密度1.109
- pKa:17.31±0.40(预测)
- PSA:25.02
- LogP:6.5402
- 蒸汽压9.76E-10 mmHg at 25 °C
- 溶解性DMSO: 10 mM
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种口服活性藻类,从咖喱叶中分离出来,防止高脂肪饮食(HFD)引起的体重增加,高脂贫血和脂肪在脂肪组织和肝脏中的积累;抑制系统性炎症和氧化性压力;改善葡萄糖的清除和肝脏和脂肪组织中对胰岛素反应性基因表现的上调.
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2-hydroxy-3-methyl-9H-carbazole (E/Z)-3,7-dimethyl-2,6-°Ctadienal 2-(benzyloxy)-1-methyl-4-nitrobenzene 3-(benzyloxy)-4-methylanilineMethyl-isopropenylcarbazol a]carbazole3,5,11-trimethyl-3-(4-methyl-pent-3-enyl)-3,11-dihydro-pyrano[3,2-a]carbazole mahanimbidine mahanimbinol合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
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主要参考文献
1: Jagtap S, Khare P, Mangal P, Kondepudi KK, Bishnoi M, Bhutani KK. Effect of mahanimbine, an alkaloid from curry leaves, on high-fat diet-induced adiposity, insulin resistance, and inflammatory alterations. Biofactors. 2017 Mar;43(2):220-231. doi: 10.1002/biof.1333. Epub 2016 Sep 24. doi: 10.4103/0973-1296.108145.
3: Dahiya J, Singh J, Kumar A, Sharma A. Isolation, characterization and quantification of an anxiolytic constituent - mahanimbine, from Murraya koenigii Linn. Spreng Leaves. J Ethnopharmacol. 2016 Dec 4;193:706-711. doi: 10.1016/j.jep.2016.10.014. Epub 2016 Oct 11. doi: 10.12659/MSM.911013.
5: Pandit S, Kumar M, Ponnusankar S, Pal BC, Mukherjee PK. RP-HPLC-DAD for simultaneous estimation of mahanine and mahanimbine in Murraya koenigii. Biomed Chromatogr. 2011 Sep;25(9):959-62. doi: 10.1002/bmc.1561. Epub 2011 Mar 4. doi: 10.1016/j.fitote.2010.07.013. Epub 2010 Jul 23. doi: 10.1016/S2095-4964(17)60352-2. doi: 10.1002/ptr.3023. doi: 10.3390/molecules171214449. doi: 10.1002/chem.201301792. Epub 2013 Sep 12. doi: 10.3390/molecules16119651.
合成参考文献
参考文献:10.1248/cpb.40.230
摘要:ITO C, OKAHANA N, WU T, WANG M, LAI J, KUOH C, FURUKAWA H. New Carbazole Alkaloids from Murraya euchrestifolia. Chem. Pharm. Bull. 1992;40(1):230–2. doi: 10.1248/cpb.40.230.
参考文献:10.1016/s0031-9422(00)90494-1
摘要:Reisch J, Adebajo AC, Kumar V, Aladesanmi AJ. Two carbazole alkaloids from Murraya koenigii. Phytochemistry. 1994 Jul;36(4):1073–6. doi: 10.1016/s0031-9422(00)90494-1.
参考文献:10.1055/s-0036-1590877
摘要:Sahoo A, Prabagar B, Ghosh N. Cyclization and Cycloisomerization of π-Tethered Ynamides: An Expedient Synthetic Method to Construct Carbo- and Heterocycles. Synlett. 2017 Sep 13;28(19):2539–55. doi: 10.1055/s-0036-1590877.
参考文献:10.1002/chin.199808206
摘要:CHAKRABARTY M, NATH AC, KHASNOBIS S, CHAKRABARTY M, KONDA Y, HARIGAYA Y, KOMIYAMA K. ChemInform Abstract: Carbazole Alkaloids from Murraya koenigii. ChemInform. 1998 Feb 24;29(8). doi: 10.1002/chin.199808206.
参考文献:10.1055/s-0036-1589091
摘要:Wang T, Oswood C, Hoye T. Trapping of Hexadehydro-Diels–Alder Benzynes with Exocyclic, Conjugated Enals as a Route to Fused Spirocyclic Benzopyran Motifs. Synlett. 2017 Aug 22;28(20):2933–5. doi: 10.1055/s-0036-1589091.
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