CAS: 2091-46-5; Triphenyl(Prop-2-Yn-1-yl)Phosphonium Bromide
该化合物是一种四磷盐,其特征是其propargyl功能组,该化合物主要用于有机合成,作为一种多用途试剂,尤其是通过核生殖增殖或循环增殖反应形成碳-碳键,其磷元素多能增强反应,使其在Wittig型发泡和其他磷介质变异中具有价值.propargyl 组进一步允许参与化学,如铜催化氮-氮-烷循环(CuAAC)等点击化学.该化合物在标准条件下的稳定性和明确界定的再活动特征使其在制药和材料科学研究中成为建设复杂分子结构的可靠选择.它通常在不成熟的条件下处理,以保持纯度.
- 英文名称Triphenyl(Prop-2-Yn-1-yl)Phosphonium Bromide
- 中文名称三苯基(丙-2-炔-1-基)溴化鏻
- IUPAC名称triphenyl(prop-2-yn-1-yl)phosphonium bromide
- 其它别名炔丙基三苯基溴化膦; Triphenylpropargylphosphonium Bromide
- CAS编号2091-46-5
- MFCD编号:MFCD00011811
- EINECS号:218-242-2
- FDA UNII编号:4EH6786QFV
- 分子式:C21H18BrP分子量:381.25
- 产品CID: 1067984
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P264-P270-P280-P302+P352-P330-P362+P364-P501
- UN编号UN 2811 6.1/PG 3
- 危险品标志Xn
- 安全声明26-36/37
- 危险类别码20/21/22-36/37/38
- WGK Germany3
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
CAS号106-96-7 溴代丙炔 | CAS号603-35-0 三苯基膦 | CAS号35225-79-7 联甲基苯乙烯酮 | CAS号1896-62-4 反式苯亚甲基丙酮 | CAS号28691-76-1 Phosphonium,tri... | CAS号28447-16-7 4-(pyridin-3-yl... | CAS号134029-62-2 3,4,5,4'-四甲氧基二苯乙烯 | CAS号134029-49-5 (Z)-3,4,5,4’-四甲... | CAS号2236-01-3 丙酮基三苯基溴化膦 | CAS号55047-62-6 4-(4-tert-butyl...合成工艺路线路线简述
- 合成目标产物 Propargyltriphenylphosphonium Bromide 主要起始原料 Propargyl Bromide And Triphenylphosphine
- (文献来源)合成步骤主要原料 Propargyl Bromide 和 Triphenylphosphine
📜3-溴丙炔,三苯基膦置于氢溴酸体系中,化学反应生成炔丙基三苯基溴化膦
参考文献:消除-加法.第十八部分.胺和醇与羧酸和烯丙基all盐的加合物酰化
标题:消除-加法.第十八部分.胺和醇与羧酸和烯丙基all盐的加合物酰化
摘要:制备了溴化二甲基丙-2-炔基溴化;;它容易在中性或碱性介质中异构化为烯丙基异构体.碱催化的羧酸向烯丙基盐的亲核加成反应很容易发生,加合物(即活化的乙烯基酯)与胺和醇快速反应,生成酰胺和酯.在这样的反应中,可以制备salt盐并将其用作原位的酰化催化剂.在某些条件下,The中心的脱烷基反应会发生酰化反应.
Doi:10.1039/j39690001904
海关参考信息
- 2901292000-乙炔
2902200000-苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
专利号:JP-WO2009063910-A1
优先权日:2007-11-12
标 题 :Catalytic asymmetric synthesis of optically active isoxazoline compounds
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Efficient Approaches To The Stereoselective Synthesis Of Chiral 2-Alkoxydienes And Heterodienes作者:José Barluenga,Miguel Tomás,Luis A. López,Angel Suárez-Sobrino |发布日期:1997.8
摘要:Three Approaches To Dienes Having A Chiral Alkoxy Group At C-2 Are Shown. Alkoxypropenylphosphonium Salts 3 Undergo Stereoselective Wittig Reaction Affording High Yields Of Racemic And/or Homochiral 2-Menthyloxy-, 2-(8-Phenylmenthyloxy)-, 2-Trans-Phnylcyclohexyloxy- And 2-Trans-Mesitylcyclohexyloxybuta-1,3-Dienes 5A-J (Method A). Esters Derived From Chiral Alcohols 6 Are Methylenated With Dimethyltitanocene To Yield Chiral Dienes 5A, E, 7 (Method B). Chiral î+/--Alkoxyacroleins 8 Are Prepared By The Aza-Wittig Reaction Of 3 Followed By Imine Hydrolysis And Utilized For Synthesizing Various Types Of Activated Chiral Alkoxycarbodienes 10, 12 And 14 (Method C), As Well As 3-Alkoxy-1-Azabutadiene Derivatives 15.
合成参考文献
摘要:Larsen, R. D.; Cai, D., Science of Synthesis, (2005) 15, 439.
📝 需求与反馈
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