CAS: 13885-13-7; 2-Cyclopropyl-2-Oxoacetic Acid

相似化合物

519164-14-8 5617-84-5 42251-78-5

环丙基甲基甲醇置于lead(Iv) Acetate,Calcium Carbonate体系中,用 苯 用作溶剂,化学反应生成2-环丙基-2-氧代乙酸
参考文献:Reaktionen Von Bleitetraacetat Mit Alicyclischen Alkoholen,Iii.环丙基和环丁基甲醇.18. Mitteilung黚reaktionen麻省理工学院bleitetraacetat †往最†往最
标题:Reaktionen Von Bleitetraacetat Mit Alicyclischen Alkoholen,Iii.环丙基和环丁基甲醇.18. Mitteilung黚reaktionen麻省理工学院bleitetraacetat †往最†往最
摘要:当用四乙酸铅处理时,环丙基甲醇和环丙基甲基甲醇不会由于中间形成环丙基自由基而产生β片段化产物.然而,Cyclopropylmethylcarbinol得到其来自oc的碎裂产物的少量α ç β键断裂涉及甲基的去除.相反,环丁基甲醇以18%的收率经历β片段化反应,同时形成未重排的乙酸环丁酯和重排的乙酸环丙基甲基酯.这些结果表明,按以下顺序增加了自由基稳定性:环丙基<甲基<环丁基,而在环丁基甲醇的四乙酸铅反应中分离异构体的乙酸酯则进一步证明了在β片段化过程中,最初生成的碳自由基片段处于在最终产物形成之前,大部分被氧化为相应的碳离子.
Doi:10.1002/hlca.19690520429

专利信息

专利号:US-6033882-A
优先权日:1994-07-07
标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
发明人：HOLBROOK JOSEPH JOHN; WILLIS CHRISTINE LOUISE; JOHNSEN KEYJI; HATELEY MARTIN JOHN
权利人:GENZYME CORP
摘要:PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.

专利号:US-2016319312-A1
优先权日:2013-07-29
标 题 :Synthesis method for l-cyclic alkyl amino acid and pharmaceutical composition having thereof
发明人：HONG HAO; ZHENG CHANGSHENG; GUO LINA
权利人:ASYMCHEM LABORATORIES (TIANJIN) CO LTD; ASYMCHEM LIFE SCIENCE (TIANJIN) CO LTD; TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD; ASYMCHEM LABORATORIES (FUXIN) CO LTD; JILIN ASYMCHEM LABORATORIES CO LTD
摘要:A synthesis method for L-cyclic alkyl amino acid and a pharmaceutical composition having the said amino acid are provide in the present disclosure provides. The synthesis method comprises: step A.) preparing a cyclic alkyl keto acid or a cyclic alkyl keto acid salt having Structural Formula (I) or Structural Formula (II), and step B.) mixing the cyclic alkyl keto acid or the cyclic alkyl keto acid salt with ammonium formate, a leucine dehydrogenase, a formate dehydrogenase and a coenzyme NAD + , and carrying out a reductive amination reaction to generate the L-cyclic alkyl amino acid, wherein the Structural Formula (I) is n n n n n n n n n n where n 1 ≧1, m 1 ≧0 and the M 1 is H or a monovalent cation; the Structural Formula (II) is n n n n n n n n n n where n 2 ≧0, m 2 ≧0, the M 2 is H or a monovalent cation, an amino acid sequence of the leucine dehydrogenase is SEQ ID No.1.

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.