CAS: 135673-97-1; Fmoc-Cha-Oh

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(fluorenylmethoxy)carbonyl chloride L-2-cyclohexylalanine L-cyclohexylalanine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide((S)-1-tert-Butylcarbamoyl-2-cyclohexyl-ethyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

L-环己基丙氨酸,9-芴甲基-N-琥珀酰亚胺基碳酸酯置于sodium Carbonate体系中,用 1,4-二氧六环,水 用作溶剂,化学反应 18.0H,以71%的收率获得fmoc-β-环己基-L-丙氨酸
参考文献:真菌双加氧酶asqj是混杂的且是双峰的:喹诺酮类与喹唑啉酮类的底物定向形成
标题:真菌双加氧酶asqj是混杂的且是双峰的:喹诺酮类与喹唑啉酮类的底物定向形成
摘要:先前的研究表明,Fe Ii /α-酮戊二酸依赖性双加氧酶asqj诱导构巢曲霉在viridicatin生物合成中的骨架重排,从苯并[1,4]二氮杂-2,5-二酮底物生成喹诺酮骨架.我们报告说,仅通过改变苯并二氮杂二酮底物中的取代基,Asqj即可催化另外的,完全不同的反应.通过底物筛选,功能探针的应用和计算分析来建立这种新机制.Asqj消费税h 2由合适的苯并[1,4]二氮杂-2-5,5-二酮底物的杂环结构生成co,生成喹唑啉酮.这种新颖的asqj催化途径由复杂底物中的单个取代基控制.Asqj的这种独特的底物定向反应性可实现喹诺酮或喹唑啉酮的靶向生物催化生成,喹诺酮或喹唑啉酮是两种具有特殊生物医学相关性的生物碱框架.
Doi:10.1002/anie.202017086

专利信息

专利号:US-6143722-A
优先权日:1996-11-26
标 题 :Heptapeptide oxytocin analogues
发明人：MELIN PER; NILSSON ANDERS; TROJNAR JERZY; AURELL CARL-JOHAN; RIVIERE PIERRE; HAIGH ROBERT
权利人:FERRING BV
摘要:PCT No. PCT/SE97/01968 Sec. 371 Date Aug. 2, 1999 Sec. 102(e) Date Aug. 2, 1999 PCT Filed Nov. 21, 1997 PCT Pub. No. WO98/23636 PCT Pub. Date Jun. 4, 1998Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal beta -aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the beta -aminoalcohol Z is -NR-CH(Q)-CH2OH, Q is (CH2)n-NH-A is H or -C(=NH)NH2, and R is CH3 or C2H5, and the moiety S wherein H is a D-aromatic alpha -aminoacid and Y is an aliphatic alpha -aminoacid and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions.

专利号:US-5859190-A
优先权日:1997-02-04
标题 :Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
发明人：MEYER JEAN-PHILIPPE; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of hydantoin and thiohydantoin compounds. The present invention further provides the compounds made by the combinatorial synthesis.

专利号:US-11279734-B2
优先权日:2017-12-01
标 题:Solution-phase affinity selection of inhibitors from combinatorial peptide libraries
发明人：PENTELUTE BRADLEY L; TOUTI FAYCAL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention provides novel peptides (e.g., peptides, macrocyclic peptides, mini-proteins) that modulate protein-protein interactions or salts thereof, and methods of making and using the inventive peptides. In some embodiments, the peptides are high affinity inhibitors (e.g., K D of at most 100 nM, at most 10 nM, at most 1 nM) of a protein-protein interaction. In certain embodiments, these peptides interfere with p53-MDM2 binding interactions (e.g., by binding to MDM2 (GenBank® Gene ID: 4193)). In some embodiments, the peptides interfere with the dimerization of the C-terminal domain of the human immunodeficiency virus (HIV) capsid protein (C-CA), comprising residues 146-231 of the HIV capsid protein (e.g., by binding to the C-terminal domain of the HIV capsid protein (C-CA), thereby inhibiting the dimeric interface of HIV capsid protein, thereby inhibiting viral assembly). These inventive peptides were rapidly generated and identified using novel methods described herein comprising combinatorial peptide synthesis and/or solution affinity selection.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:CN-116535459-A
优先权日:2023-04-12
标题 :A kind of phenolic acid compound and its synthesis method and application