CAS: 133-06-2; Captan

该化合物是一种化学化合物,主要用作农业杀真菌剂,以保护作物免受各种真菌疾病的感染;它被归类为二恶英,以其广泛种类的活动防止影响水果,蔬菜和装饰植物的病原体而闻名;卡普坦似乎是白色的,在白外晶体固体中比较稳定,在正常条件下相对稳定,尽管它可以在强酸或碱地上降解;它的行动方式涉及干扰真菌的细胞呼吸,有效地抑制其生长和生殖;卡普坦在水中可溶性中中,波动性较低,有助于其农业应用的功效;然而,必须指出,卡普坦由于潜在的健康和环境影响,包括可能作为人类致癌物的分类,受到监管审查,因此在许多国家对其使用进行监管,并在处理和应用时建议采取安全防范措施,以尽量减少接触风险.

结构式图片

欧盟法规

统一分类与标签压力设备指令-第1组危险流体REACH注册ECHA物质食品接触材料-禁用CMR物质工作场所安全标识要求欧盟农药活性物质C&L通报化妆品禁用物质清单ECHA物质REACH预注册废弃物危险特性清单

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CAS号3268-87-9 1,2,3,4,6,7,8,9... | CAS号1746-01-6 硫丙磷 | CAS号72918-21-9 1,2,3,7,8,9-Hex...

合成工艺路线路线简述

    Sodium;3-Oxo-3A,4,7,7A-Tetrahydroisoindol-1-Olate,三氯硫氯甲烷 反应生成克菌丹
    参考文献:Antohe,N.;Sauciuc,A.;Neamt,P.;Ionescu,M.;Lupu,V.;Cristea,V.;Bordian+
    标题:Antohe,N.;Sauciuc,A.;Neamt,P.;Ionescu,M.;Lupu,V.;Cristea,V.;Bordian+

    海关参考信息

    专利信息


    专利号:WO-2004011474-A1
    优先权日:2002-07-31
    标题:Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-6653468-B1
    优先权日:2002-07-31
    标 题 :Universal support media for synthesis of oligomeric compounds
    发明人:GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

    专利号:US-4810649-A
    优先权日:1984-04-06
    标题:Controlled regeneration of zea diploperennis hybrids and breeding strategies therewith
    发明人:SONDAHL MARO R; EVANS DAVID A; PRIOLI LAUDENIR
    权利人:DNA PLANT TECHN CORP
    摘要:This invention provides a method for high frequency plant regeneration from somatic stem donor tissue of field grown Zea diploperennis, a diploid, perennial corn ancestor with high tillering capacity. This species is used as a parent in a maize improvement strategy to transfer the unique traits of high tillering and plantlet regeneration capacity into cultivated corn. After 3-4 subcultures of cultured somatic tissues on a primary medium, small callus fragments are transferred to a secondary medium devoid of the auxin, 2,4-D. After a few days, numerous shoots regenerate and develop into normal plantlets which are then separated and transferred to a tertiary medium for root development. The selection of somaclonal variants form cultured somatic cells of interspecific hybrids between corn and teosinte are used for the synthesis of unique breeding lines suited for development of improved corn varieties. A protocol for gene transfer employing recombinant DNA techniques is also described.

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-5231085-A
    优先权日:1988-10-31
    标题 :Compositions and methods for the enhancement of host defense mechanisms
    发明人:ALEXANDER J WESLEY; BABAYAN VIGEN K; BLACKBURN GEORGE L; CERRA FRANK B; DALY JOHN; GERSOVITZ MITCHELL T; KINSELLA JOHN E; LICARI JEROME J; RUDOLPH FREDERICK; VAN BUREN CHARLES T
    权利人:SANDOZ LTD
    摘要:The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount of n a) a compound associated with the synthesis of polyamines, n b) a nucleobase source, n c) omega-3 polyunsaturated fatty acids, and n d) omega-6 polyunsaturated fatty acids n the use of such compositions and their manufacture.
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    主要参考文献


    1: Nesakumar N, Sethuraman S, Krishnan UM, Rayappan JB. Cyclic voltammetric acetylcholinesterase biosensor for the detection of captan in apple samples with the aid of chemometrics. Anal Bioanal Chem. 2015 Jun;407(16):4863-8. doi: 10.1007/s00216-015-8687-1. Epub 2015 Apr 21. doi: 10.1016/j.toxlet.2011.09.023. Epub 2011 Sep 29. doi: 10.1007/s00128-015-1705-3. Epub 2015 Nov 26. doi: 10.1111/1556-4029.12154. Epub 2013 May 21. doi: 10.1038/jes.2015.54. Epub 2015 Sep 16.
    6: Berthet A, Bouchard M, Danuser B. Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. J Appl Toxicol. 2012 Mar;32(3):194-201. doi: 10.1002/jat.1653. Epub 2011 Mar 5. doi: 10.1080/19440049.2013.790088. Epub 2013 May 28. doi: 10.1093/annhyg/mer008. Epub 2011 Mar 22.
    9: Boran H, Capkin E, Altinok I, Terzi E. Assessment of acute toxicity and histopathology of the fungicide captan in rainbow trout. Exp Toxicol Pathol. 2012 Mar;64(3):175-9. doi: 10.1016/j.etp.2010.08.003. Epub 2010 Sep 2. doi: 10.1080/03601234.2015.1062648. Epub 2015 Aug 7. doi: 10.1080/19440049.2013.794977. Epub 2013 Jun 7. doi: 10.1093/annhyg/mes011. Epub 2012 Mar 16. doi: 10.1021/jf1030339. Epub 2010 Dec 1. doi: 10.1002/jat.1659. Epub 2011 Mar 5. doi: 10.3109/10408444.2010.481663. Review. doi: 10.1021/es9037935. doi: 10.1007/s00216-010-4601-z. Epub 2011 Jan 13. ^

    合成参考文献


    摘要:Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe A: Medizinische Mikrobiologie und Parasitologie., 234(110), 1976 []
    摘要:Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales., 168(1173), 1974 []
    摘要:Fundamental and Applied Toxicology., 7(299), 1986
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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