CAS: 13057-17-5; Bromo(Methoxy)Methane

上下游产品

methanol formaldehyd chloromethyl methyl ether Dimethoxymethane(3-methoxyprop-1-yn-1-yl)benzene 2-(bromomethyl)naphthalene 3-methoxy-2,2-diphenyl-propionitrile ethyl 3-(bromomethyl)-4-methoxybenzoate

二甲醇缩甲醛置于zinc(II) Chloride,乙酰溴体系中,用 Neat (No Solvent) 用作溶剂,化学反应生成溴甲基甲基醚
参考文献:用于多用途混合缩醛的路易斯酸催化合成烷氧基甲基卤化物;范围和限制
标题:用于多用途混合缩醛的路易斯酸催化合成烷氧基甲基卤化物;范围和限制
摘要:摘要:本文详细介绍了路易斯酸催化制备结构异构的烷氧甲基卤代物的过程.评估了一系列具有不同卤化试剂的路易斯酸对双烷氧甲烷的裂解,发现几种易得的路易斯酸表现出高催化潜力.Socl2与mgcl2的组合被发现是在无溶剂条件下制备结构多样的烷氧甲基卤代物最好的选择之一.该方法的有效性已被证明,可以通过烷氧甲基化磷,硫,氮和含氧亲核试剂来获得广泛的混合缩醛.本方法具有简单性,普适性,快速性和试剂的可获得性等显著优点.
Doi:10.2174/1570178619666220112105145

专利信息

专利号:US-8183402-B2
优先权日:2007-06-27
标 题:Industrial method for the synthesis of 17-acetoxy-11β[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
发明人：BODI JOZSEF; VISKY GYOERGY; SZELES JANOS; MAHO SANDOR; SANTA CSABA; CSOERGEI JANOS; TUBA ZOLTAN; TERDY LASZLO; MOLNAR CSABA; ARANYI ANTAL; HORVATH ZOLTAN; BALOGH GABOR
权利人:BODI JOZSEF; VISKY GYOERGY; SZELES JANOS; MAHO SANDOR; SANTA CSABA; CSOERGEI JANOS; TUBA ZOLTAN; TERDY LASZLO; MOLNAR CSABA; ARANYI ANTAL; HORVATH ZOLTAN; BALOGH GABOR; RICHTER GEDEON NYRT
摘要:The present invention relates to a process for the synthesis of the 17-acetoxy-11β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): n nfrom 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):

专利号:US-5597931-A
优先权日:1992-03-30
标 题:Total synthesis of taxol and analogues thereof
发明人：DANISHEFSKY SAMUEL J; MASTERS JOHN; YOUNG WENDY; LINK J THOMAS; ISAACS RICHARD; SNYDER LAWRENCE B
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

专利号:US-5488116-A
优先权日:1992-03-30
标 题:Total synthesis of taxol and analogues thereof
发明人：DANISHEFSKY SAMUEL J; BORNMANN WILLIAM G; QUENEAU YVES; MAGEE THOMAS V; KROL WALTER J; MASTERS JOHN J; JUNG DAVID K
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

专利号:US-10760063-B2
优先权日:2014-10-20
标 题:Modified template-independent enzymes for polydeoxynucleotide synthesis
发明人：EFCAVITCH J WILLIAM; TUBBS JULIE L; SINHA PREM; STEC BOGUSLAW
权利人:MOLECULAR ASSEMBLIES INC
摘要:The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3′-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.

专利号:US-9428524-B2
优先权日:2010-05-25
标 题:Synthetic process for the manufacture of ecteinascidin compounds
发明人：MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN
权利人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN; PHARMA MAR SA
摘要:This invention relates to compounds of formula II: wherein R 1 , R 2 , Prot SH , and Prot NH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.

专利号:US-11390858-B2
优先权日:2014-10-20
标 题:Modified template-independent enzymes for polydeoxynucleotide synthesis
发明人：TUBBS JULIE L; SINHA PREM; STEC BOGUSLAW; WILSON CHRISTOPHER; EFCAVITCH J WILLIAM; SAMMOND DEANNE W
权利人:MOLECULAR ASSEMBLIES INC
摘要:The invention includes methods for identifying polymerases, such as modified terminal nucleotidyl transferases (TdT), that are capable of binding nucleotides comprising removable 3′-O-blocking moieties to a nucleic acid initiator, without the use of a template. The invention further includes the identified polymerases, and methods of using the polymerases for de novo synthesis of predetermined oligonucleotide sequences.