CAS: 129-24-8; 3-Hydroxy-4-Phenylquinolin-2(1H)-One

上下游产品

3-Hydroxy-1-(4-Methoxybenzyl)-4-Phenylquinolin-2(1H)-One 1134192-59-8
3-羟基喹啉-2-酮 3-Hydroxyquinolin-2(1H)-One 26386-86-7

📜3-羟基喹啉-2-酮置于n-溴代丁二酰亚胺(Nbs),四(三苯基膦)钯,Sodium Carbonate体系中,用 乙二醇二甲醚,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成纯绿青霉素
参考文献:Dirhodium(II)/dbu 金属-有机体系催化靛红与重氮乙酸乙酯的扩环反应:获得 Viridicatin 生物碱的途径
标题:Dirhodium(II)/dbu 金属-有机体系催化靛红与重氮乙酸乙酯的扩环反应:获得 Viridicatin 生物碱的途径
摘要:我们在此介绍了 Nhc-二铑 (II)/dbu 催化的靛红与重氮乙酸乙酯的扩环反应.这种新的一锅法产生了 3-羟基-2(1H)-Oxoquinoline-4-Carboxylate 核心,区域选择性和非常好的收率.Dft 机理研究表明,3-羟基吲哚-重氮中间体和二铑 (II) 络合物之间的金属卡宾形成是反应的限速步骤.合成的 3-羟基-2(1H)-氧喹啉-4-羧酸乙酯核心可以很容易地转化为绿色生物碱,通过微波辅助的 3-羟基-4-Suzuki-Miyaura 交叉偶联,产率高达 80%.溴喹啉-2(1H)-一种与芳基硼酸.
Doi:10.1002/ejoc.201300796

专利信息

专利号:US-6261811-B1
优先权日:1998-12-22
标 题 :Synthesis of natural product metabolites using immobilized fungal spores
发明人：HAMDY MOSTAFA K
权利人:UNIV GEORGIA RES FOUND
摘要:Natural product metabolites produced by fungi are synthesized using fungal spores that have been immobilized onto/into a support. Supports that can be used include loofah sponge, synthetic sponge, powdered cellulose paper, wood shavings, calcium alginate gel beads, agar gel beads, channeled aluminum beads, polypropylene beads and glass beads. Immobilizing the fungal spores provides accelerated production of the natural product metabolite in a standard bioreactor. Fungi that can be used include Penicillium cyclopium, Penicillium chrysogenum, Penicillium citrinum, Trichoderma viride, Aspergillus terreus and Monascus ruber. In a preferred embodiment, spores of Penicillium cyclopium NRRL 6233 immobilized with loofah sponge are cultured in a nutrient media for at least 4 days to produce compactin which is a hypocholesteremic agent.

专利号:WO-0037665-A1
优先权日:1998-12-22
标 题:Method and system for the continuous synthesis of natural products using immobilized fungal spores