CAS: 12192-57-3; Aurothioglucose
该化合物是一种含金化合物,主要用于治疗风湿类关节炎,被归类为金色色色素,黄金与硫醇组和葡萄糖类混合物相协调,该化合物具有抗炎特性,其原因是金离子能够调节免疫反应.Aurothioglucose通常通过肌肉内注射进行,以其行动缓慢而闻名,通常需要几个星期才能产生治疗效果.该化合物具有副作用,包括皮肤疹,胃肠炎和对肾脏和肝脏的潜在毒性,在治疗期间必须定期监测.其行动机制不完全理解,但相信涉及抑制大型脂肪活动和细胞生产调节.与其他基于金色的疗法一样,使用黄色素类素的情况随着新的,更有效的治疗风湿类节炎的出现而减少,但它仍然是一项重要的历史治疗选择.
- 英文名称Aurothioglucose
- 中文名称葡糖硫金
- IUPAC名称Aurothioglucose
- 其它别名Gold(1+); (3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxane-2-Thiolate; Gold Thioglucose; Sr
- CAS编号12192-57-3
- MFCD编号:MFCD00056080
- EINECS号:235-365-7
- FDA UNII编号:2P2V9Q0E78
- 分子式:C6H11AuO5S分子量:392.18
- 产品CID: 306900
- 同类组份化合物CAS12192-57-3 (anhydrous)
- 产品分类原料药 → 其它化学药
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6908761-B1
优先权日:1999-11-04
标题:Transcriptional activators
发明人：KATAOKA KOHSUKE
权利人:OTSUKA PHARMA CO LTD
摘要:The invention provides a synthesis-inducible eucaryotic promoter having a transcriptional activity comprising, for example, a heavy metal-sensitive DNA sequence, derived from a natural promotor, of a base sequence of any one of SEQ ID NOS: 1 to 4; an inducer of the transcriptional activation activity thereof; a recombinant expression vector comprising a site for the insertion of an extraneous gene ligated to the above promotor: a eucaryotic expression kit comprising eucaryotic cells transfected with the above vector and the above inducer; and a method for expression of an extraneous gene in a eucaryotic system by using the same
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主要参考文献
1: DRACHMAN RH, TEPPERMAN J. Aurothioglucose obesity in the mouse. Yale J Biol Med. 1954 Apr;26(5):394-409.
2: Dillard CJ, Hu ML, Tappel AL. Effect of aurothioglucose on glutathione and glutathione-metabolizing and related enzymes in rat liver and kidney. Chem Biol Interact. 1987;64(1-2):103-14. doi: 10.1016/0009-2797(87)90064-0. 27(2):230-2. doi: 10.1002/art.1780270217. 129(1):194-8. doi: 10.1093/jn/129.1.194. 10(2):369-83. 61(2):173-4. German. doi: 10.1007/s003930200026. 60(5):359-60. German. doi: 10.1007/s003930170036. 3 Suppl
1:51-6. doi: 10.1007/BF03342622. 9(4):535-51. doi: 10.1016/0738-081x(91)90083-w. 40(1):148-54. doi: 10.1016/0014-4800(84)90072-8. 141(6):349-51. 22(3):194-9. doi: 10.1111/j.1399-0039.1983.tb01191.x. 20(9):1632-3. 32(6):1026-30. 287(45):38210-9. doi: 10.1074/jbc.M112.392225. Epub 2012 Sep 13.
合成参考文献
摘要:
摘要:McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 2003. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2003 (Plus Supplements)., p. 2849
摘要:U.S. Pharmacopeia. The United States Pharmacopeia, USP 26/The National Formulary, NF 21; Rockville, MD: U.S. Pharmacopeial Convention, Inc., p195 (2003)
摘要:O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 153
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