CAS: 120-05-8; (Z)-2-(3,4-Dihydroxybenzylidene)-6-Hydroxybenzofuran-3(2H)-One

该化合物是一种化学化合物,属于氟氯素类,具体地说是一种氟氯酚,其特点是黄色晶状外观,以潜在的生物活动,包括抗氧化剂特性而著称.硫酸盐经常研究它对各种生物系统的影响,包括其在调制细胞过程及其潜在治疗应用中的作用.该化合物溶解于有机溶剂中,但溶解于水中,其结构具有一种氟化物骨骼,它在许多植物衍生的化合物中很常见,有助于其活性以及与生物分子的相互作用.对硫酸盐的研究突出了其在健康和疾病方面的潜在好处,特别是在其抗炎和...

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6-hydroxybenzofuran-3-one 3,4-dihydroxybenzaldehyde sulphuretin 3'-O-β-glucopyranoside (Z)-2-(3,4-dimethoxybenzylidene)-6-methoxybenzofuran-3(2H)-oneZ)-3,4-diacetoxy-benzylidene)-benzofuran-3-one6-acetoxy-2-((Z)-3,4-diacetoxy-benzylidene)-benzofuran-3-one 2-(3,4-dihydroxybenzyl)-6-hydroxybenzofuran-3(2H)-one

合成工艺路线路线简述

    📜(Z)-2-(3,4-Dimethoxybenzylidene)-6-Methoxybenzofuran-3(2H)-One置于三溴化硼体系中,用 二氯甲烷 用作溶剂,以95%的收率获得2-(3,4-二羟基苯亚甲基)-6-羟基-3(2H)-苯并呋喃酮
    参考文献:实用的,模块化的和一般的通过金催化的分子间炔烃氧化策略合成3-香豆酮的方法
    标题:实用的,模块化的和一般的通过金催化的分子间炔烃氧化策略合成3-香豆酮的方法
    摘要:已经开发了一种金催化的分子间炔烃氧化方法,用于制备3-香豆素.使用8-异丙基喹啉n-氧化物作为氧化剂,邻乙炔基苯甲醚的反应可提供中等至非常好的分离产率的多功能3-香豆醛酮.该化学方法的合成效用还通过天然产物硫酸脂的合成来表明.
    Doi:10.1002/asia.201403032

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    专利信息


    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:US-7592436-B2
    优先权日:1998-04-17
    标题:Gene encoding a protein having aurone synthesis activity
    发明人:SAKAKIBARA KEIKO; FUKUI YUKO; TANAKA YOSHIKAZU; KUSUMI TAKAAKI; MIZUTANI MASAKO; NAKAYAMA TORU
    权利人:INT FLOWER DEV PTY LTD
    摘要:The present invention provides a protein having aurone synthase activity involved in the color of flowers such as snapdragons, a gene that encodes it, cDNA in particular, and its applications. This gene can give yellow color to the flowers of plants by introducing into plants deficient in chalcone isomerase and so forth and expressing.

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    主要参考文献


    1: Jiang P, Sun H. Sulfuretin alleviates atopic dermatitis-like symptoms in mice via suppressing Th2 cell activity. Immunol Res. 2018 Oct;66(5):611-619. doi: 10.1007/s12026-018-9025-4. pii: E2753. doi: 10.3390/ijms18122753.
    3: Roh K, Kim S, Kang H, Ku JM, Park KW, Lee S. Sulfuretin has therapeutic activity against acquired lymphedema by reducing adipogenesis. Pharmacol Res. 2017 Jul;121:230-239. doi: 10.1016/j.phrs.2017.05.003. Epub 2017 May 5. doi: 10.1007/s11010-015-2537-5. Epub 2015 Aug 11. doi: 10.1016/j.neuroscience.2015.07.030. Epub 2015 Jul 17. doi: 10.3390/ijms15058863.
    7: Kwon SH, Ma SX, Lee SY, Jang CG. Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. Neurochem Int. 2014 Jul;74:53-64. doi: 10.1016/j.neuint.2014.04.016. Epub 2014 May 4.

    合成参考文献


    摘要:Calleja, P.; Dorel, R.; Echavarren, A. M., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 520.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.3390/ijms15058863
    摘要:Lee DS, Kim KS, Ko W, Li B, Jeong GS, Jang JH, Oh H, Kim YC. The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. Int J Mol Sci. 2014 May 19;15(5):8863–77.
    参考文献:10.1186/s12906-019-2566-9
    摘要:Varela-Rodríguez L, Sánchez-Ramírez B, Rodríguez-Reyna IS, Ordaz-Ortiz JJ, Chávez-Flores D, Salas-Muñoz E, Osorio-Trujillo JC, Ramos-Martínez E, Talamás-Rohana P. Biological and toxicological evaluation of Rhus trilobata Nutt. (Anacardiaceae) used traditionally in mexico against cancer. BMC Complementary Medicine and Therapies. 2019 Jul 01;19(1):153. doi: 10.1186/s12906-019-2566-9.
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