📜十三烷二酸置于乙二醇体系中,200.0 °C,266.64 Pa 条件下,反应生成十三烷二酸环乙撑酯 参考文献:Meta And Para Rings1 标题:Meta And Para Rings1 摘要: Doi:10.1021/ja01308A047
专利信息
专利号:US-5936100-A 优先权日:1996-12-16 标 题:Synthesis of functionalized macrocycles by ring closing metathesis 发明人:FUERSTNER ALOIS; LANGEMANN KLAUS; KINDLER NICOLE 权利人:STUDIENGESELLSCHAFT KOHLE MBH 摘要:The invention concerns an improved process for the preparation of macrocyclic products with 12 or more ring atoms containing one or more polar functional groups on the ring and/or one or more heteroatoms within the ring by ring closing metathesis (RCM) of suitably substituted diene precursors even if the substrates are devoid of any kind of conformational preorganization. Metal carbene complexes of Ru, Mo, W, Re, Os, which are tolerant towards the respective functional group and can either be isolated or prepared in situ are used as catalysts or catalyst precursors. Preferred catalysts or catalyst precursors are ruthenium complexes of the general type XX1LL1Ru=CRR1, wherein X, X1=halogen, L, L1=trialkylphosphine, R, R1=H, Ph, CH=CPh2 denote the most preferred embodiment. The process can be applied to the synthesis of olfactory compounds, perfumary ingredients, pheromones, crown ethers, antibiotics and pharmaceuticals for human and veterinary medicine.
专利号:US-2024343859-A1 优先权日:2021-10-06 标题:Poly(ethylene brassylate-co-dioxanone) copolymers, method of synthesis and biomedical devices made therefrom 发明人:KIESEWETTER MATTHEW; PICARD KASSIE; POTHUPITIYA JINAL; SALTZMAN W MARK 权利人:UNIV OF RHODE ISLAND BOARD OF TRUSTEES; UNIV YALE 摘要:Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.
专利号:WO-0155129-A1 优先权日:2000-01-27 标题:Synthesis of macrocyclic monomers 发明人:LEITNER WALTER; JANSSEN EDO; FUERSTNER ALOIS; PICKENHAGEN WILHELM; PANTEN JOHANNES 权利人:STUDIENGESELLSCHAFT KOHLE MBH; DRAGOCO GERBERDING CO AG; LEITNER WALTER; JANSSEN EDO; FUERSTNER ALOIS; PICKENHAGEN WILHELM; PANTEN JOHANNES 摘要:A method for the production of a macrocyclic monomer ( for example, ethylene brassylate) comprises the following steps: treatment of a polymer (for example, polyethylene brassylate) with a supercritical fluid, under conditions which bring about a depolymerisation of the polymer to macrocyclic monomers, extraction of the macrocyclic monomer, with the supercritical fluid as extraction agent and separation of the supercritical fluid from the macrocyclic monomer. The extraction can be carried out continuously and/or simultaneous to the treatment of the polymer with the supercritical fluid.
专利号:US-8440608-B2 优先权日:2004-08-06 标题:Beta-substituted tetrandropyrana (on) s and method for the synthesis and the use thereof 发明人:MANE JEAN; CHANOT JEAN-JACQUES; SCHROEDER MARTIN 权利人:MANE JEAN; CHANOT JEAN-JACQUES; SCHROEDER MARTIN; MANE FILS V 摘要:The invention relates, in particular to a tetrahydropyran(on) compound which is substituted in position beta with respect to a cycle oxygen of formula (I), wherein a substituent R is a linear alkyl radical in C2:C10 including, (CH 3 ) 2 CH— or C 6 H 5 —(CH 2 ) m —, with m=0 or 1, or formula (II), wherein A is —CH 2 — or —CO—, in the form of an odorant and to a method for the synthesis thereof by reducing oxo-ester. The use of the inventive compound in composition such as perfumery compositions in the ordinary sense of the term i.e. topic, in particular cosmetic compositions and care products.
专利号:WO-2018192923-A1 优先权日:2017-04-18 标题 :Alpha alkylation of aldehyde with a polycyclic olefin 发明人:QUINTAINE JULIE; MACMILLAN DAVID W C 权利人:FIRMENICH & CIE 摘要:The present invention relates to the field of organic synthesis and more specifically to the alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide compound of formula (I) in the form of any one of its stereoisomers or a mixture thereof and wherein R represents a hydrogen atom or C 1-8 linear alkyl group; R 1 , R 2 , R 3 and R 4 represent, when taken separately, independently of each other, a hydrogen atom or a C 1-2 linear alkyl group or a C 3-4 linear or branched alkyl group; or R 2 and R 3 , when taken together, represent a C 4-10 linear, branched or cyclic alkanediyl group and n is 1 or 2.
专利号:US-2020368149-A1 优先权日:2019-05-23 标 题:Topical Anesthetic Composition and Method of Synthesis 发明人:JOHNSON WENDY 权利人:JOHNSON WENDY 摘要:A topical anesthetic composition for pain relief. The composition includes an anesthetic, such as bupivacaine, formulated for topical administration and transdermal delivery of the anesthetic. The composition can be applied to the skin of an individual to alleviate localized pain due to acute or chronic injuries or health conditions.
[参考文献]: Aline Vieille-Petit, Et Al. Metrics And Clinical Relevance Of Percutaneous Penetration And Lateral Spreading. Skin Pharmacol Physiol. 2015;28(2):57-64.
合成参考文献
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198