CAS: 92886-86-7; Tert-Butyldiphenylsilyl Trifluoromethanesulfonate

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CAS号1493-13-6 三氟甲烷磺酸 | CAS号92886-83-4 tert-butyl(trip... | CAS号2923-28-6 三氟甲烷磺酸银 | CAS号58479-61-1 叔丁基二苯基氯硅烷 | CAS号591-51-5 苯基锂

叔丁基二苯基氯硅烷 以 乙醚,氯仿,环己烷 作为反应溶剂,化学反应 24.0H,反应生成 三氟甲磺酸叔丁基二苯基硅烷基酯
参考文献:Vloon,W. J.; Bos,J. C. Van Den; Willard,N. P.,Recueil Des Travaux Chimiques Des Pays-Bas,1991,Vol. 110,# 10,P. 414-419
标题:Vloon,W. J.; Bos,J. C. Van Den; Willard,N. P.,Recueil Des Travaux Chimiques Des Pays-Bas,1991,Vol. 110,# 10,P. 414-419

专利信息

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-4895939-A
优先权日:1986-02-24
标题:High percentage β-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel high beta -yield producing novel intermediates of the formula where R4 is useful in the synthesis of 1- beta -alkyl carbapenems.

专利号:US-5663342-A
优先权日:1994-03-08
标 题 :2-chloro and 2-bromo derivatives of 1,5-iminosugars
发明人：BARTA THOMAS E; MUELLER RICHARD A
权利人:SEARLE & CO
摘要:Novel 2-chloro and 2-bromo derivatives of 1,5-iminosugars are disclosed, especially such derivatives of 1,5-dideoxy-1,5-imino-D-glucitol. These compounds are useful inhibitors of glucosidase enzymes and also are useful as antiviral agents and as intermediates for the synthesis of other enzyme inhibitors and antiviral compounds.

专利号:US-4772683-A
优先权日:1986-02-24
标 题:High percentage beta-yield synthesis of carbapenem intermediates
发明人：MARTEL ALAIN; DARIS JEAN-PAUL; CORBEIL JACQUES
权利人:BRISTOL MYERS CO
摘要:Disclosed herein is a novel process using novel silyl enol ether intermediates of the formula 8 to generate novel azetidione thiolester intermediates of the formula 12 which can be used to form 1- beta -alkyl carbapenem antibiotics. It has now been discovered that if the R4 group is selected from a small group of moieties having the formula: an increased beta -yield of up to approximately 100% can be obtained.

专利号:WO-2025104679-A1
优先权日:2023-11-16
标题 :Processes for making intermediates for isoindolinone inhibitors of the mdm2-p53 interaction having anticancer activity
发明人：SHAKYA SAGAR; JOHNSON MATT; WONG NICHOLAS; BODHURI PRABHUDAS; DAVAR NIPUN
权利人:OTSUKA PHARMA CO LTD
摘要:The present disclosure relates to processes for preparing synthetic intermediates for the synthesis of isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity.