专利号:WO-2024189634-A1 优先权日:2023-03-13 标 题 :Highly atom economical process for synthesis of novel co-initiator for photo-induced radical polymerisation 发明人:KAPAT DR AJOY; AHMAD ASRAR; MITTAL GARVISHA 权利人:SHIV NADAR INSTITUTION OF EMINENCE DEEMED TO BE UNIV 摘要:The present invention relates to a base catalyzed sequential conjugate addition reaction for the synthesis of a novel and efficient co-initiator for Photo Induced Radical Polymerization. The process comprises synthesis of new co-initiator having 6,5 and 6,6-bicyclic scaffolds as central core. The process comprises reacting thiocarboxylic acid, catechol, thiocatechol, benzodithiol, benzothiocatechol and binol with ketone substrates at room temperature with a base and a solvent to yield the novel co-initiator compound of Formula 3, Formula 5, Formula C and Formula Z.
专利号:US-10889599-B2 优先权日:2018-02-27 标 题:1,1-diborylalkyl-1-metal compounds, preparation method thereof, and their applications toward synthesis of 1,1-diboronate ester compounds 发明人:CHO SEUNG HWAN; LEE YEOSAN 权利人:POSTECH ACAD IND FOUND 摘要:The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.
专利号:WO-2025119975-A1 优先权日:2023-12-04 标 题:A method for synthesis of harmine 发明人:HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN 权利人:RECONNECT LABS AG 摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.
专利号:US-8901352-B2 优先权日:2011-01-13 标题 :Method for the synthesis of rasagiline 发明人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN 权利人:REIS ÖMER; KOYUNCU HASAN; ESIRINGU ILKER; SAHIN YASEMIN; GULCAN H OZAN; NOBEL ILAÇ SANAYII VE TICARET A S 摘要:We have developed a new method for the synthesis of Rasagiline (Formula 1) based on the alkylation of trifluoroacetyl protected aminoindan. This protection enabled us to carry out an alkylation of aminoindan with a high yield and purity under very mild conditions with a wide range of reaction conditions and reagent selection. Considering the ease, purity and high yields of introducing and removal of the trifluoroacetyl group, this approach is a highly practical and economical way for the synthesis of rasagiline or its pharmaceutically acceptable salts.
专利号:US-8859763-B1 优先权日:2013-05-17 标题 :Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 发明人:VAYSSE-LUDOT LUCILE; LE FLOHIC ALEXANDRE; VAULTIER MICHEL; PUCHEAULT MATHIEU; KAMINSKI THOMAS 权利人:SERVIER LAB 摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
专利号:WO-2022155981-A1 优先权日:2021-01-25 标题 :USE OF N-HETEROCYCLIC CARBENE-BASED COMPOUNDED NICKEL (II) COMPLEX IN SYNTHESIS OF α-BENZYL BENZOFURAN COMPOUND 发明人:SUN HONGMEI; SHUI YU; JIN WENHUI 权利人:UNIV SOOCHOW 摘要:Disclosed is the use of an N-heterocyclic carbene-based compounded nickel (II) complex in the synthesis of an α-benzyl benzofuran compound. In the present invention, an air-stable compounded nickel (II) complex Ni[P(OEt) 3 ]{[R`NC(CH 3 )C(CH 3 )NR`]C}Br 2 is used as a catalyst, wherein R` is 2,4,6-trimethylphenyl, and the α-benzyl benzofuran compound is synthesized by means of a hydrogen heteroarylation reaction of an aryl ethylene compound and a benzofuran compound in the presence of an organic base. The operability and substrate applicability of the catalyst are obviously better than those of the prior art, and meanwhile, the nickel catalyst has a higher practical application value due to the air stability and easiness of synthesis thereof.