63762-78-7 = 82846-18-2 反应条件:1.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water 标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives 作者:Claudi,Francesco; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12]
63762-79-8 = 82846-18-2 反应条件:1.1 Reagents: Dimethyl Sulfate,Potassium Carbonate Solvents: Acetone2.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water 标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives 作者:Claudi,Francesco; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12]
452-84-6 = 82846-18-2 反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid,Copper Sulfate Solvents: Water2.1 Reagents: Dimethyl Sulfate,Potassium Carbonate Solvents: Acetone3.1 Reagents: Pyridine,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water 标题:Synthesis And Dopamine Receptor Affinities Of 2-(4-Fluoro-3-Hydroxyphenyl)Ethylamine And N-Substituted Derivatives 作者:Claudi,Francesco; Et Al 参考文献:Journal Of Medicinal Chemistry 日期:1990 卷标:33(9) 页码:2408-12
4-氟-3-羟基苯甲酸置于水,Potassium Carbonate,Sodium Hydroxide体系中,用 甲醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 14.0H,反应生成 4-氟-3-甲氧基苯甲酸 参考文献: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask 标题: Heterocyclic Compounds For The Inhibition Of Pask[fr] Composés Hétérocycliques Pour L'Inhibition De Pask 摘要:本文披露了新的杂环化合物和组合物,以及它们作为药物治疗疾病的应用.还提供了抑制pas激酶(pask)在人类或动物主体中活性的方法,用于治疗疾病,如糖尿病.
专利号:US-2023192718-A1 优先权日:2018-03-30 标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof 发明人:SANDANAYAKA VINCENT 权利人:NIROGY THERAPEUTICS INC 摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.
专利号:CN-111727190-A 优先权日:2017-12-28 标题 :A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application
专利号:US-11919905-B2 优先权日:2017-12-28 标题 :Substituted benzo[f]imidazo[1,2-a][1,4]diazepines as anesthetics 发明人:QI YOUMAO 权利人:HANGZHOU ADAMERCK PHARMLABS INC 摘要:Disclosed are a pyridyl imidazobenzodiazepine propionate (compound 1) and the synthesis and use thereof. Also provided are intermediates for the preparation. Compound 1 provided by the present invention has an obvious venous anesthesia activity equivalent to that of the positive control drug remimazolam p-toluenesulfonate or remimazolam besylate. In addition, compound 1 can be significantly reduced in mouse model experiments, and same can even overcome common limb jitters, head tilting, opisthotonus and other side effects caused by the remimazolam besylate or remimazolam p-toluenesulfonate as a drug during development in preclinical animal experiments, thereby allowing same to be used in the preparation of intravenous anesthetics. The structural general formula of compound 1 is as follows, wherein each group and substituent are as defined in the description.
专利号:CN-111727190-B 优先权日:2017-12-28 标题 :A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application
专利号:CN-108033964-B 优先权日:2017-12-28 标 题:A kind of pyridyl imidazobenzodiazepine propionate compound and its synthesis and application
参考文献:10.1007/bf00409646 摘要:Kranzfelder G, Hartmann RW, von Angerer E, Schönenberger H, Bogden AE. 3,4-Bis(3′-hydroxyphenyl)hexane — A new mammary tumor-inhibiting compound. Journal of Cancer Research and Clinical Oncology. 1982 May;103(2):165–80. doi: 10.1007/bf00409646.