CAS: 791616-63-2; (11Br)-4-Hydroxy-2,6-Bis(2,4,6-Triisopropylphenyl)Dinaphtho[2,1-D:1',2'-F][1,3,2]Dioxaphosphepine 4-Oxide

📜Magnesium,1,3,5-Tri(Propan-2-yl)Benzene-6-Ide,Bromide置于吡啶,Bis(Triphenylphosphine)Nickel(II) Chloride,水,三溴化硼,三乙胺,三氯氧磷体系中,用 乙醚,二氯甲烷,水 作为反应溶剂,化学反应 59.0H,反应生成 (11Bs)-4-羟基-2,6-二[2,4,6-三(异丙基)苯基]-二萘并[2,1-D:1',2'-F][1,3,2]二氧杂磷杂卓4-氧化物
参考文献:对映选择性有机催化氟化诱导的wagner-Meerwein重排
标题:对映选择性有机催化氟化诱导的wagner-Meerwein重排
摘要:在应变下破裂:应变的烯丙基环丁醇和环丙醇很容易经历如标题重排所描述的环膨胀.该反应通过催化量为1来促进,并且相对于底物范围显示出高耐受性.相应的β-氟螺酮产品以高收率和出色的立体选择性被分离出来.edg =给电子基团,Ewg =吸电子基团.
DOI:10.1002/anie.201303527

专利信息

专利号:US-10918627-B2
优先权日:2016-05-11
标 题:Convergent and enantioselective total synthesis of Communesin analogs
发明人：MOVASSAGHI MOHAMMAD; LATHROP STEPHEN PAUL; POMPEO MATTHEW W; CHANG WEN-TAU TIMOTHY
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I): n nor a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 -R 8 and m, n, r, s, t, and u are as defined herein, is provided. Methods of making such compounds are also disclosed as are methods for the treatment of cancer, various infectious diseases, and abnormal cardiovascular function.

专利号:US-10640508-B2
优先权日:2017-10-13
标 题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n nwherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.

专利号:US-2017342077-A1
优先权日:2016-05-24
标题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n n n n n n n n n n wherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.

专利号:US-7517828-B2
优先权日:2003-04-25
标 题 :Chiral broensted acid catalyst for asymmetric synthesis and method of asymmetric synthesis with the catalyst
发明人：AKIYAMA TAKAHIKO
权利人:TOAGOSEI CO LTD
摘要:A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.

专利号:US-9309165-B2
优先权日:2012-12-19
标 题 :6-chloro-3-(phenyl-d5)-inden-1-one and use thereof
发明人：JACOBSEN MIKKEL FOG; BRANDES SEBASTIAN
权利人:LUNDBECK & CO AS H
摘要:The present invention discloses the compound 6-chloro-3-(phenyl-d 5 )-inden-1-one (I) and routes of synthesis to obtain (I). In a further aspect the present invention discloses the use of (I) for the synthesis of (S)-6-chloro-3-(phenyl-d 5 )-indan-1-one.

专利号:US-2017333405-A1
优先权日:2016-05-11
标题:Convergent and enantioselective total synthesis of communesin analogs