CAS: 66711-21-5; Apraclonidine

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CAS号65936-26-7 N-(2,6-Dichloro... | CAS号73218-65-2 2,6-dichloro-1-... | CAS号81913-29-3 Clonidine 4-iso...

📜2,6-二氯-4-硝基苯胺置于氯化亚砜,磺酰氯,Hydrazine Hydrate,5%-Palladium/activated Carbon,乙酸酐,三乙胺体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 21.41H,反应生成 阿可乐定
参考文献:盐酸阿普乐定制备方法的改进
标题:盐酸阿普乐定制备方法的改进
摘要:青光眼是损害视神经并可能导致视力丧失的眼部疾病的总称.视神经损伤的主要原因是眼压(iop),除了...
DOI:10.1080/00304948.2016.1206429

专利信息

专利号:US-2019374478-A1
优先权日:2016-12-06
标题:Ultrastable Gold Nanoparticles For Drug Delivery Applications And Synthesis Thereof
发明人：BOISSELIER ÉLODIE; OUELLETTE MATHIEU; PERNET VINCENT; OMAR MAHMOUD
权利人:UNIV LAVAL
摘要:Herein presented are gold nanoparticles (AuNPs) used for the transport of medications to mucous membranes. The AuNPs are ultra-stable in that they withstand freeze-drying and heating treatments without noticeable change in their structure. In addition, they interact with mucous membranes, and therefore allow transport of certain drugs to these mucous membranes, allowing higher exposure time of the drugs, hence decreased dosing schedule of administration.

专利号:US-6172066-B1
优先权日:1996-05-16
标 题:Dihydropyrimidines and uses thereof
发明人：NAGARATHNAM DHANAPALAN; WONG WAI C; MIAO SHOU WU; PATANE MICHAEL A; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-6228861-B1
优先权日:1995-11-16
标题 :Dihydropyrimidines and uses thereof
发明人：NAGARATHNAM DHANAPALAN; WONG WAI C; MIAO SHOU WU; GLUCHOWSKI CHARLES; PATANE MICHAEL A
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-6387909-B1
优先权日:1999-07-30
标 题 :Thienopyranecarboxamide derivatives
发明人：LEONARDI AMEDEO; MOTTA GIANNI; RIVA CARLO; TESTA RODOLFO
权利人:RECORDATI CHEM PHARM
摘要:The invention relates to novel N-(substituted phenyl)-N'-[omega-(5-substituted-7-oxo-7H-thieno[3,2-b]pyran-3-carbonylamino)alkyl]piperazines their N-oxides and pharmaceutically acceptable salts thereof. The compounds are endowed with enhanced selectivity for alpha1-adrenergic receptors and a low activity in lowering blood pressure. The compounds are useful in the treatment of obstructive syndromes of the lower urinary tract, including benign prostatic hyperplasia (BPH), and in the treatment of lower urinary tract symptoms (LUTS) and neurogenic lower urinary tract dysfunction (NLUTD). The compounds are also useful in the treatment of excessive intraocular pressure, cardiac arrhythmia, erectile dysfunction, sexual dysfunction, and for inhibiting cholesterol synthesis or reducing sympathetically mediated pain.

专利号:US-6245773-B1
优先权日:1996-05-16
标题:5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines
发明人：WONG WAI C; LAGU BHARAT; NAGARATHNAM DHANAPALAN; MARZABADI MOHAMMAD R; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to dihydropyrimidine compounds of the following formula: n which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-2007148246-A1
优先权日:2005-08-11
标题:Nucleic Acid-Based Matrixes
发明人：LUO DAN; LI YOUGEN
权利人:LUO DAN; LI YOUGEN
摘要:Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include delivery of biologically active agents, cell and tissue culture, and cell-free protein synthesis.