CAS: 65031-96-1; (S)-Oxiran-2-Ylmethyl Butyrate

该化合物是一种手性过氧化物酯,其特点是反应性氧气环和丁诺酸功能组,该化合物对合成有机化学具有兴趣,因为它能够参与环开反应,从而能够形成更复杂的手性中间体. (2S) 配置确保不对称合成的对等选择性,使其对制药和精细化学应用具有价值.它的丁诺酸碱性提高了有机溶剂的溶解性,便利了各种反应条件下的处理.该化合物在受控条件下的稳定性及其作为建筑块的多功能强调了其在形成立体化学定型分子中的效用.建议在惰性条件下妥善储存,以保持其再活动性.

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60456-26-0 7501-44-2 60456-26-0

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合成工艺路线路线简述

  • 合成目标产物 (S)-(+)-Glycidyl Butyrate 主要起始原料 Butyryl Chloride And (R)-(+)-Glycidol
  • (文献来源)合成步骤主要原料 Butyryl Chloride 和 (R)-(+)-Glycidol
缩水甘油丁酯 以 四氢呋喃 作为反应溶剂,以44%的收率获得产物(S)-丁酸缩水甘油酯
参考文献:Practical Access To Highly Enantioenriched C-3 Building Blocks Via Hydrolytic Kinetic Resolution
标题:Practical Access To Highly Enantioenriched C-3 Building Blocks Via Hydrolytic Kinetic Resolution
摘要:
DOI:10.1021/jo981332D

海关参考信息

专利信息


专利号:US-9233989-B2
优先权日:2011-10-11
标题:Sila analogs of oxazolidinone derivatives and synthesis thereof
发明人:REDDY DUMBALA SRINIVASA; BALAMKUNDU SEETHARAM SINGH; RAMESH REMYA
权利人:COUNCIL SCIENT IND RES
摘要:The invention discloses silaanalogs of oxazolidinone compounds, to pharmaceutical compositions and to the synthesis of the oxazolidinone derivatives of formula I. The invention further relates to methods of treating a subject suffering with gram positive pathogens including those resistant to methicillin and vancomycin using the compound(s) or modulation of coagulation properties of blood-clotting cascade or compositions of the oxazolidinone derivatives of the invention.

专利号:US-9376400-B2
优先权日:2005-06-08
标 题:Process for the synthesis of triazoles
发明人:CHEN SHILI; LOU RONGLIANG; WU YUSHENG; ZHOU JIACHENG; HANSELMANN ROGER
权利人:MELINTA THERAPEUTICS INC
摘要:The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

专利号:US-8895741-B2
优先权日:2003-06-03
标 题:Process for the synthesis of biaryl oxazolidinones
发明人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG
权利人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG; MELINTA THERAPEUTICS INC
摘要:The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

专利号:US-6743811-B2
优先权日:1999-07-28
标 题:Oxazalidinone compounds and methods of preparation and use thereof
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7220870-B2
优先权日:1995-03-14
标 题:Hydrolytic kinetic resolution of cyclic substrates
发明人:JACOBSEN ERIC N; TOKUNAGA MAKOTO; LARROW JAY F
权利人:HARVARD COLLEGE
摘要:The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.
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主要参考文献

[参考文献]: Arnaldo Glogauer, Et Al. Identification And Characterization Of A New True Lipase Isolated Through Metagenomic Approach. Microb Cell Fact. 2011 Jul 15:10:54.

合成参考文献


参考文献:10.1186/1475-2859-10-54
摘要:Glogauer A, Martini VP, Faoro H, Couto GH, Müller-Santos M, Monteiro RA, Mitchell DA, de Souza EM, Pedrosa FO, Krieger N. Identification and characterization of a new true lipase isolated through metagenomic approach. Microbial Cell Factories. 2011 Jul 15;10(1):54. doi: 10.1186/1475-2859-10-54.
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