CAS: 625-45-6; 2-Methoxyacetic Acid

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79-14-1 3938-96-3 1738-36-9

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CAS号50-00-0 甲醛 | CAS号201230-82-2 carbon monoxide | CAS号50402-70-5 sodium methoxya... | CAS号1738-36-9 甲氧基乙腈 | CAS号115-10-6 二甲醚 | CAS号124-38-9 二氧化碳 | CAS号133604-76-9 3,5-dimethylphe... | CAS号3938-96-3 甲氧基乙酸乙酯 | CAS号1056469-59-0 (R)-N-(2-heptyl... | CAS号162929-44-4 2-methoxy-N-[(1... | CAS号104703-38-0 N-(4-Bromopheny... | CAS号38870-89-2 甲氧基乙酰氯 | CAS号3938-96-3 甲氧基乙酸乙酯 | CAS号201230-82-2 carbon monoxide | CAS号4957-14-6 二对甲苯基甲烷 | CAS号21895-17-0 BENZENE,1-METHY... | CAS号4455-77-0 甲氧甲基(二苯基)氧化膦 | CAS号1794-90-7 2-Nitro-1,3-pro... | CAS号20758-58-1 2-methoxyacetate | CAS号625-48-9 2-硝基乙醇

氰基甲醇 甲醛氰醇置于盐酸体系中,化学反应生成 甲氧基乙酸
参考文献:Gauthier,Annales De Chimie (Cachan,France),1909,Vol. <8>16,P. 318
标题:Gauthier,Annales De Chimie (Cachan,France),1909,Vol. <8>16,P. 318

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.