CAS: 622-37-7; Phenyl Azide

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CAS号591-50-4 碘苯 | CAS号98-80-6 苯硼酸 | CAS号108-86-1 溴苯 | CAS号53694-87-4 1-AZIDO-4-IODOB... | CAS号54467-96-8 1-Azido-3-iodob... | CAS号54467-95-7 1-Azido-2-iodob... | CAS号100-63-0 苯肼 | CAS号87344-98-7 1-nitroso-1-phe... | CAS号2684-02-8 benzenediazonium | CAS号1075-50-9 N-trimethylstan... | CAS号108656-89-9 4-[(2-chlorophe... | CAS号108656-90-2 5-[(2-chlorophe... | CAS号34296-51-0 1-苯基-1H-1,2,3-噻... | CAS号59401-82-0 1-phenyl-1,2,3-... | CAS号5388-42-1 2-苯基-1-氧代二氢氮杂茚 | CAS号54446-36-5 4-溴苯基苯胺 | CAS号61613-22-7 (2-溴苯基)苯胺 | CAS号88280-58-4 N-(3-溴苯基)苯胺 | CAS号330-83-6 4-氟二苯胺

📜苯肼置于ferric Nitrate体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以63%的收率获得产物叠氮苯
参考文献:用粘土支撑的硝酸铁有效地将肼转化为叠氮化物
标题:用粘土支撑的硝酸铁有效地将肼转化为叠氮化物
摘要:使用极其廉价的粘土负载硝酸铁,可以在温和的条件下在二氯甲烷中以高收率制备叠氮化物.
DOI:10.1016/0040-4039(84)80109-4

专利信息

专利号:US-5571677-A
优先权日:1993-07-02
标题:Convergent synthesis of branched and multiply connected macromomolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which.complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:US-5830658-A
优先权日:1995-05-31
标 题 :Convergent synthesis of branched and multiply connected macromolecular structures
发明人：GRYAZNOV SERGEI M
权利人:LYNX THERAPEUTICS INC
摘要:The invention provides methods and compositons for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moities capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations.

专利号:US-6410643-B1
优先权日:2000-03-09
标题 :Solid phase synthesis method and reagent
发明人：SWANSON MELVIN J
权利人:SURMODICS INC
摘要:A reagent composition adapted to be coated onto a support surface in order to provide that surface with a high density of reactive groups. The surface, thus coated, can be used for any suitable purpose, and is particularly well suited for use as a solid phase synthesis support surface. The synthesis support surface, in turn, can be used in repetitive and combinatorial syntheses such as the synthesis of polynucleotides, polypeptides and polysaccharides. The polymeric coating can be used to provide increased effective surface area, particularly in situations in which the effective area of the support surface is itself limited, as on the surface of a silicon wafer. In so doing, the polymeric coating provides an optimal combination of such properties as reactive density and surface area or volume.

专利号:US-8017323-B2
优先权日:2003-03-26
标 题 :Free reactant use in nucleic acid-templated synthesis
发明人：LIU DAVID R; SAKURAI KAORI
权利人:HARVARD COLLEGE
摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.