CAS: 61658-41-1; Furomollugin

该化合物是源于Rubia colonifolia(印度疯人院)根部的生物活性呋喃,具有显著的药理特性,包括抗炎,抗氧化剂和抗癌活动. 具有结构特征的呋喃环与凝固石内核结合,富罗穆洛金展示了调控细胞路径的潜力,如NF-B和MAPK信号.它能够研究自由基和抑制亲炎细胞素,因此成为治疗研究的候选对象.该复合物的稳定性和选择性生物活动凸显了其在研究氧化性应激紊乱和肿瘤抑制机制方面的效用. Furomolugin主要用于临床前研究,以了解分子目标的机能.

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3-((E)-3-hydroxy-3-methyl-but-1-enyl)-1,4-dioxo-1,4-dihydro-naphthalene-2-carboxylic acid methyl ester 1,4-dihydroxy-3-((E)-3-hydroxy-3-methyl-but-1-enyl)-naphthalene-2-carboxylic acid methyl ester 2-methoxycarbonyl-1,4-naphthoquinone oxomollugin

合成工艺路线路线简述

    📜1-羟基-4-甲氧基-2-萘甲酸甲酯置于ammonium Cerium (Iv) Nitrate,对甲苯磺酸体系中,用 甲醇,水,甲苯,乙腈 作为反应溶剂,化学反应 18.5H,反应生成 呋喃大叶茜草素; 5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯
    参考文献:A Four-Step Total Synthesis Of Radermachol
    标题:A Four-Step Total Synthesis Of Radermachol
    摘要:Radermachol Has Been Synthesized In Four Steps And An Overall Yield Of 22% Via Key Ytterbium Triflate Catalyzed Furannulation And Intramolecular Nucleophilic Acylation Reactions.
    DOI:10.1021/ol500862W

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    主要参考文献

    参考标题:A Novel And Efficient Synthesis Of Diverse Dihydronaphtho[1,2-B]Furans Using The Ceric Ammonium Nitrate-Catalyzed Formal [3 + 2] Cycloaddition Of 1,4-Naphthoquinones To Olefins And Its Application To Furomollugin
    作者:Likai Xia,Yong Rok Lee
    摘要:A Novel Approach Was Developed For The Synthesis Of Diverse Dihydronaphtho[1,2-B]Furans From 1,4-Naphthoquinones And Olefins In The Presence Of Ceric Ammonium Nitrate. This Reaction Provides A Rapid Route For The Synthesis Of A Variety Of Dihydronaphtho[1,2-B]Furans And Naphtho[1,2-B]Furans Bearing Different Substituents. This Methodology Was Also Used To Synthesize The Biologically Important Natural

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    合成方法参考DOI号:10.1039/c3ob40977e
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