CAS: 59378-75-5; 1-(Tert-Butoxycarbonyl)Pyrrolidine-3-Carboxylic Acid

相似化合物

72925-16-7 140148-70-5 72580-53-1

上下游产品

methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate 1-benzylpyrrolidine-3-carboxylic acid methyl ester methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate Dimethyl itakonate 3-iodo-pyrrolidine-1-carboxylic acid tert-butyl ester benzyl 1-{tert-butyloxycarbonyl}pyrrolidine-3-carboxylate 5-methoxy-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1'-carboxylic acid tert-butyl ester N-(2-iodo-4-methoxyphenyl)-1-{tert-butyloxycarbonyl}pyrrolidine-3-carboxamide

1-Boc-3-羟甲基吡咯烷置于1-羟基环己基苯基甲酮,Sodium Hydroxide体系中,用 乙二醇二甲醚 作为反应溶剂,以65%的收率获得产物1-Boc-吡咯烷-3-甲酸
参考文献:通过氢原子转移将伯醇和醛氧化成羧酸
标题:通过氢原子转移将伯醇和醛氧化成羧酸
摘要:伯醇和伯醛氧化成相应的羧酸是有机合成中的基本反应.在本文中,我们报告了一种用于氧化伯醇和醛的新化学选择性工艺.这种无金属反应具有新的氧化剂,易于操作的程序,高分离产率以及即使在易受攻击的仲醇和叔丁烷亚磺酰胺存在下也具有非常好至优异的官能团耐受性的特点.
DOI:10.1021/acs.Orglett.1C02188

专利信息

专利号:US-2024390383-A1
优先权日:2021-09-28
标题 :Dioxazines and their use in treatment of gba-related diseases
发明人：NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH
权利人:ZEVRA DENMARK AS
摘要:The present invention relates to dioxazines, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

专利号:WO-2015088564-A1
优先权日:2013-12-13
标 题:P2x4 receptor modulating compounds
发明人：NEWCOM JASON S; SPEAR KERRY L
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.