CAS: 57395-48-9; 10-Azido-1-Decanol

该化合物是一种化学化合物,其特点是附在脱卡诺尔主干柱上,特别是在终端位置,有亚齐德功能组(-N3),该化合物一般在室内温度下无色可粉黄,在室内温度下可溶于有机溶剂,而水中的溶解性因脱卡诺的脱卡诺链的疏水性而受到限制.亚齐德组引入独特的再活性,使其在各种合成应用中有用,特别是在可参与循环增加反应的点击化学中.长碳氢化合物链的存在会助长其亲脂性,影响其与生物膜的相互作用,影响其在交付药物过程中的潜在应用或作为表面活性剂的相互作用.然而,由于化物的内在不稳定性,特别是在热或冲击下,必须谨慎处理,以减轻与其爆炸性相关的风险.

结构式图片

欧盟法规

C&L通报

合成工艺路线路线简述

    📜1,10-癸二醇置于4-二甲氨基吡啶,Sodium Azide,三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 24.0H,反应生成 10-叠氮基-1-癸醇
    参考文献:由机械键合两亲双稳态 [2]Rotaxane 构建的聚集体的可调荧光和形态
    标题:由机械键合两亲双稳态 [2]Rotaxane 构建的聚集体的可调荧光和形态
    摘要:设计并制备了一种新型机械键合两亲物(mba)-双稳态[2]轮烷h2 .在溶液和聚集状态下,由于存在距离依赖性光诱导电子转移 (Pet) 过程,H2均表现出 Ph 响应性发射.此外,由于ph控制的穿梭运动引起h2两亲性的交替,H2聚集体的形态可以从纳米球调整为囊泡.
    DOI:10.1002/chem.202302132

    海关参考信息

    专利信息


    专利号:US-2024109924-A1
    优先权日:2021-01-29
    标 题 :Ip4-4,6 substituted derivative compounds
    发明人:PÉREZ FERRER MARÃ?A DEL MAR; FERRER REYNÉS MIQUEL DAVID; BASSISSI MOHAMAD FIRAS; SALCEDO ROCA CAROLINA; SERRA COMAS CARME; CATENA RUIZ JUAN LORENZO; LLEBARIA SOLDEVILA AMADEU; ORTEGA CASTRO JOAQUÃ?N; PERELLÓ BESTARD JOAN
    权利人:SANIFIT THERAPEUTICS S A
    摘要:The present invention provides IP4-4,6 substituted derivatives, their methods of synthesis and their uses. In some aspects, the IP4-4,6 derivative is a compound of formula I wherein R1, R3, R7, and R11 are OPO32−, and R5 and R9 are selected from the group consisting of —O(Alkyl)nX, —O(Alkyl)yCy(Alkyl2)y-Z, —O(Alkyl)yA(Alkyl)y-Z′, and their thiophosphate analogs. Also provided are methods, pharmaceutical compositions and formulations, methods of use, articles of manufacture, and kits for the treatment of diseases and conditions such as pathological crystallization-related diseases and conditions.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Stereodivergent Synthesis Of Right- And Left-Handed Iminoxylitol Heterodimers And Monomers. Study Of Their Impact On β-Glucocerebrosidase Activity
    作者:Fabien Stauffert,Jenny Serra-Vinardell,Marta Gómez-Grau,Helen Michelakakis,Irene Mavridou,Daniel Grinberg,Lluïsa Vilageliu,Josefina Casas,Anne Bodlenner,Antonio Delgado,Philippe Compain
    摘要:A Library Of Dimers And Heterodimers Of Both Enantiomers Of 2-O-Alkylated Iminoxylitol Derivatives Has Been Synthesised And Evaluated On β-Glucocerebrosidase (Gcase), The Enzyme Responsible For Gaucher Disease (Gd). Although The Objective Was To Target Simultaneously The Active Site And A Secondary Binding Site Of The Glucosidase, The (−)-2-Iminoxylitol Moiety Seemed Detrimental For Imiglucerase Inhibition
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