CAS: 5232-99-5; Ethyl 2-Cyano-3,3-Diphenylacrylate

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CAS号119-61-9 二苯甲酮 | CAS号105-56-6 氰乙酸乙酯 | CAS号1013-88-3 二苯甲酮亚胺 | CAS号631-61-8 乙酸铵 | CAS号64-19-7 冰醋酸 | CAS号71-43-2 苯 | CAS号3531-24-6 3,3-二苯基丙烯腈 | CAS号10380-41-3 2-Cyano-3,3-dip... | CAS号35491-55-5 2-cyano-3,3-dip... | CAS号6197-30-4 奥克立林

二苯甲酮,氰乙酸乙酯置于溶剂黄146,β-丙氨酸体系中,用 苯 作为反应溶剂,化学反应 90.0H,以64%的收率获得产物2-氰基-3,3-二苯基丙烯酸乙酯
参考文献:I类抗心律失常药(+/-)-Cibenzoline及其类似物的合成新工艺
标题:I类抗心律失常药(+/-)-Cibenzoline及其类似物的合成新工艺
摘要:摘要 (+/-)-Cibenzoline 及其类似物的合成已通过简单的反应序列实现.二芳基氰基烯烃中间体 3 可以通过二苯甲酮与氰基乙酸乙酯的 Knoevenagel 缩合形成四取代的烯烃中间体 2,然后 Krapcho 脱乙氧基羰基化或由 β-羟基腈中间体 2' 分别消除羟基来制备.2,2-二苯基环丙烷甲腈 4 由中间体 3 通过环丙烷化合成,在催化量的硫存在下与乙二胺反应转化为 (+/-)-2-(2,2-二苯基环丙基)-2-咪唑啉 5 . 此外,获得的 2-咪唑啉以非常好到中等的产率顺利氧化为相应的咪唑 6.
DOI:10.1080/00397910802006388

专利信息

专利号:US-7662401-B2
优先权日:2002-04-08
标 题 :Administration of extracts of nonfruiting nonphotosynthetic filamentous bacteria for increasing the endogenous synthesis of superoxide dismutase
发明人：MAHE YANN; MEYBECK ALAIN
权利人:OREAL
摘要:The present invention relates to the cosmetic or pharmaceutical use of an extract of a nonfruiting nonphotosynthetic filamentous bacterium in a composition containing a cosmetically or pharmaceutically acceptable medium, as an agent increasing the endogenous synthesis of superoxide dismutase, in particular for preventing and/or limiting the formation of free radicals and/or removing the free radicals present in cells; in addition, the invention relates to a composition comprising at least one extract of Vitreoscilla filiformis and lycopene.

专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人：NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2009318592-A1
优先权日:2005-10-11
标 题 :Process for the Synthesis of Amine Ethers
发明人：FREY MARKUS; BROENNIMANN VALERIE
权利人:CIBA GEIGY CORP
摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.

专利号:US-2007191516-A1
优先权日:2004-03-15
标题 :Process for the synthesis of amine ethers
发明人：FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
权利人:FREY MARKUS; RAST VALERIE; BRAIG ADALBERT; KRAMER ANDREAS
摘要:A process for the preparation of a sterically hindered amine ether which comprises reacting a corresponding sterically hindered aminoxide with a C 5 -C 18 alk-1-ene in the presence of an organic hydroperoxide and optionally hydrogenating the resulting product as well as the product mixtures obtained therewith and their use as stabilizers and flame retardants.

专利号:US-2023047214-A1
优先权日:2020-02-03
标题:Methods for microwave synthesis of degradable polymers for drug delivery
发明人：MURATOGLU ORHUN K; ORAL EBRU; GRINDY SCOTT
权利人:MASSACHUSETTS GEN HOSPITAL
摘要:Provided herein are methods of making degradable, additive-blended polymeric materials using microwave radiation and catalysts. The methods can include incorporation of therapeutic materials into the polymeric materials. There also are provided polymeric materials made by the methods and medical devices comprising the polymeric materials made by the methods.