CAS: 4394-85-8; Morpholine-4-Carbaldehyde

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220199-85-9 360-95-2 25070-73-9

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4-((Trimethylsilyl)Methyl)Morpholine置于copper(I) Bromide体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以86%的收率获得产物n-甲酰吗啉
参考文献:空气催化铜催化α-甲硅烷基取代的叔n-烷基胺的n-甲酰化
标题:空气催化铜催化α-甲硅烷基取代的叔n-烷基胺的n-甲酰化
摘要:基于铜(i)催化的α-甲硅烷基取代的叔n的氧化,有效地制备n-甲胺的位点选择方法描述了在室温下空气中的-烷基胺.氧化规程显示出优异的官能团耐受性,因为它适用于多种胺底物以及许多生物活性分子和天然产物.此外,它还用低成本的金属盐和空气中的氧气脱除由低价金属盐介导的无配体和无添加剂的胺氧化过程,这既起到末端氧化剂的作用,又作为甲酰化试剂的一部分,这在铜催化中是前所未有的.它还提供了第一种合成方法,该方法可以在非光化学反应条件下从α-甲硅烷基胺选择性反应生成α-氨基自由基类物质作为反应中间体.
DOI:10.1039/d0Gc01242D

专利信息

专利号:US-11427596-B2
优先权日:2019-07-19
标 题:Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications
发明人：CHELVAM VENKATESH; DUDHE PREMANSH; KRISHNAN MENA ASHA; SONAWANE AVINASH
权利人:INDIAN INSTITUTE OF TECH INDORE
摘要:Embodiments herein provide fused-pyrido heterocycles such as azaindoles, carboline derivatives, furo[b]pyridines or furo[b]pyridine-isatin hybrids of Formula I.Embodiments also relate to a process for a synthesis of variety of complex pyrido-heterocycles The pyrido-heterocycles can be used for treating cancer (cervix, kidney, lung, breast and epidermal skin) and multi-drug resistant tuberculosis. These heterocycles can also be used as anti-biofilm agents against pathogenic strains, which will minimize the risk of secondary infections.

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人：HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:US-8450365-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of galanthamine
发明人：MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:US-9006425-B2
优先权日:2009-03-18
标题:Aluminum complexes and their use in the synthesis of cyclic carbonates
发明人：NORTH MICHAEL
权利人:NORTH MICHAEL; UNIV YORK
摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.