专利号:US-9181292-B2 优先权日:2011-01-05 标题 :Methods for preparation of glycosphingolipids and uses thereof 发明人:LIANG PI-HUI 权利人:LIANG PI-HUI 摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
专利号:US-4334079-A 优先权日:1980-11-03 标 题:Synthesis of substituted benzyl esters 发明人:GREENE JAMES M; BUNNELL CHARLES A 权利人:LILLY CO ELI 摘要:A process for preparing certain substituted benzyl esters of phenylacetic acids by esterification in a solvent in which the salt of the acid is insoluble, and in the presence of a phase transfer catalyst.
专利号:US-2011183958-A1 优先权日:2008-10-17 标 题 :Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase 发明人:POWELL DAVID; TRANMER GEOFFREY K 权利人:MERCK FROSST CANADA LTD 摘要:Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.
专利号:US-9533957-B2 优先权日:2012-04-06 标题:Tetrazines and method of synthezising the same 发明人:DEVARAJ NEAL K; YANG JUN 权利人:UNIV CALIFORNIA 摘要:Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines, e.g., a tetrazine of formula n nand diazonorcaradienes.