CAS: 315-22-0; Monocrotaline

该化合物是一种自然产生的藻类,主要产自植物物种* Crotaria* ,以其毒性著称;它属于具有双环结构特征,含有一种环的双环结构;单氯碱具有肝毒性,可引起肺高血压,使其成为毒理学和药理学的课题;已知该化合物在肝脏中发生代谢活化,导致形成反应性代谢物,可损害细胞结构,特别是肝脏和肺部;其行动机制涉及DNA吸附管的形成,可产生诱变效应;由于其毒性性质,单氯碱经常在环境健康和安全方面研究,特别是与某些植物有关的接触风险;此外,还在研究中用于在动物研究中模拟肺高血压,提供对疾病机制和潜在治疗方法的深入了解.

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CAS号110121-56-7 mon°Crotaline m... | CAS号35337-98-5 野百合碱N-氧化物 | CAS号109391-29-9 (4R,5S)-2-(trim... | CAS号109432-25-9 (4R,5S)-2-(trim... | CAS号109391-24-4 (2R,3R,4R)-2,3,... | CAS号109494-78-2 (2R,3R,4R)-2,3,... | CAS号121719-94-6 (2'R,3R,4S)-5-[... | CAS号121719-96-8 (2'R,2S,3R,4S)-... | CAS号23107-12-2 DEHYDRORETRONECINE | CAS号23291-96-5 Dehydromon°Crotaline | CAS号608-40-2 (2R,3S)-2,3-二甲基琥珀酸 | CAS号35337-98-5 野百合碱N-氧化物 | CAS号520-55-8 Spectabiline | CAS号25490-68-0 (12R,13R,14R)-1... | CAS号526-79-4 2,3-dimethyl-4-... | CAS号480-85-3 倒千里光裂碱

合成工艺路线路线简述

  • 合成目标产物 Monocrotaline 主要起始原料 1,3-Dioxolane-4-Acetic Acid, α,4,5-Trimethyl-5-[[2-(Trimethylsilyl)Ethoxy]Carbonyl]-, 2,3,5,7A-Tetrahydro-7-(Hydroxymethyl)-1H-Pyrrolizin-1-Yl Ester, [1α[r*(4R*,5R*)],7Aβ]- (9CI)
  • (文献来源)合成步骤主要原料 1,3-Dioxolane-4-Acetic Acid, α,4,5-Trimethyl-5-[[2-(Trimethylsilyl)Ethoxy]Carbonyl]-, 2,3,5,7A-Tetrahydro-7-(Hydroxymethyl)-1H-Pyrrolizin-1-Yl Ester, [1α[r*(4R*,5R*)],7Aβ]- (9Ci)
📜Lithium;(1R,8R)-7-[[tert-Butyl(Dimethyl)Silyl]Oxymethyl]-2,3,5,8-Tetrahydro-1H-Pyrrolizin-1-Olate置于盐酸,氢氟酸,四丁基氟化铵,三乙胺体系中,用 四氢呋喃,二氯甲烷,乙二醇,乙腈 作为反应溶剂,化学反应 5.0H,反应生成 野百合碱
参考文献:Synthesis Of Monocrotaline By Nucleophilic Macrolactonization
标题:Synthesis Of Monocrotaline By Nucleophilic Macrolactonization
摘要:
DOI:10.1021/jo00226A045

海关参考信息

专利信息


专利号:US-8987503-B2
优先权日:2013-04-30
标 题 :Process for the synthesis of aminaphtone
发明人：BALDACCI MASSIMO; ROBERTI MARINELLA
权利人:BALDACCI LAB SPA
摘要:The present invention concerns a new process for the synthesis of aminaphtone, which makes use of non-toxic solvents and reagents, under mild reaction and temperature conditions. The aminaphtone obtained with the method of the present invention also has a purity of at least 98% in weight. The method comprises the following steps: a) epoxidating menadione 1 to provide epoxide 2, b) acidifying epoxide 2 to provide hydroxynaphthoquinone 3, c) esterifying between hydroxynaphthoquinone 3 and 4-aminobenzoyl chloride to obtain compound 4, and d) reducing compound 4 in the presence of a reducing agent in water to obtain aminaphtone.

专利号:WO-2024096234-A1
优先权日:2022-11-03
标题 :Bifunctional catalyst, method for measuring brønsted acid site concentration of bifunctional catalyst, and method for determining mixing ratio of catalyst for fischer-tropsch synthesis reaction and catalyst for decomposition reaction in bifunctional catalyst
发明人：CHUN DONG HYUN; YOUN MIN HYE; RHIM GEUN BAE; KIM KWANG YOUNG
权利人:KOREA INST ENERGY RES
摘要:A bifunctional catalyst according to various embodiments of the present invention comprises: a first catalyst for a Fischer-Tropsch synthesis reaction; and a second catalyst for a decomposition reaction, wherein the first catalyst is a precipitated iron-based catalyst, and the second catalyst is a zeolite catalyst.

专利号:US-2011150843-A1
优先权日:2009-10-30
标 题 :Method for the therapeutic correction of hemophilia a by transplanting bone marrow cells
发明人：MUKHOPADHYAY ASOK; YADAV NEELAM
权利人:NAT INST IMMUNOLOGY
摘要:The transdifferentiation of bone marrow cells (BMCs) into hepatocytes can be used for the development of cellular medicine for degenerative and genetic diseases. Since the liver is the primary site of factor VIII (FVIII) synthesis, the partial replacement of mutated liver cells by healthy cells in hemophilia A (HA) could manage the severity of the bleeding disorder. The use of BMCs could be used as a therapy for the bleeding phenotype of hemophilia A and other related disorders.

专利号:US-12151231-B1
优先权日:2020-09-04
标 题:High-entropy alloy (HEA) catalysts, methods of forming HEA catalysts, and methods of using HEA catalysts
发明人：HU LIANGBING; WANG CHAO; XIE PENGFEI; YAO YONGGANG
权利人:UNIV MARYLAND; UNIV JOHNS HOPKINS
摘要:A catalytic structure has a plurality of high-entropy alloy (HEA) nanoparticles. Each HEA nanoparticle is composed of a homogeneous mixture of elements of cobalt (Co), molybdenum (Mo), and at least two transition metal elements. For example, in some embodiments, each HEA nanoparticle is a quinary mixture of Co, Mo, iron (Fe), nickel (Ni), and copper (Cu). The homogeneous mixture in each HEA nanoparticle forms a single solid-solution phase. The catalytic structure is used to catalyze a chemical reaction, for example, ammonia decomposition or ammonia synthesis. Methods for forming the catalytic structure are also disclosed.

专利号:US-2014323747-A1
优先权日:2013-04-30
标 题:Process for the synthesis of aminaphtone

专利号:BR-102014010331-A2
优先权日:2013-04-30
标 题 :PROCESS FOR THE SYNTHESIS OF AMINAFTONE

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主要参考文献


1: Zhang S, Ju G, Zhang J, Dong F. Sodium Houttuyfonate Alleviates Monocrotaline-induced Pulmonary Hypertension by Regulating Canonical Transient Receptor Potential Channel Proteins via CHIP. Eur J Pharmacol. 2026 Apr
17:178874. doi: 10.1016/j.ejphar.2026.178874. Epub ahead of print. 40(3):e70078. doi: 10.1111/fcp.70078.
15:e16. doi: 10.1017/jns.2026.10077.

合成参考文献


参考文献:10.1016/s0031-9422(00)85653-8
摘要:Crout DHG. Pyrrolizidine alkaloids. The co-occurrence of monocrotaline and trichodesmine in Crotalaria recta steud. ex A. rich. Phytochemistry. 1968 Aug;7(8):1425–7. doi: 10.1016/s0031-9422(00)85653-8.
参考文献:10.1021/np50029a001
摘要:Pilbeam DJ, Lyon-Joyce AJ, Bell EA. Occurrence of the Pyrrolizidine Alkaloid Monocrotaline in Crotalaria Seeds. J. Nat. Prod. 1983 Sep;46(5):601–5. doi: 10.1021/np50029a001.
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