专利号:US-8143437-B2 优先权日:2002-02-19 标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof 发明人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X 权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC 摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
专利号:US-2005239725-A1 优先权日:2002-02-19 标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
专利号:US-7560483-B2 优先权日:2002-02-19 标题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
专利号:US-2009239950-A1 优先权日:2002-02-19 标 题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
专利号:US-2003171303-A1 优先权日:2002-02-19 标 题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
专利号:WO-03077902-A1 优先权日:2002-02-19 标 题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
参考文献:10.1007/s00216-017-0189-x 摘要:Chen Z, Chen J, Pan D, Li H, Yao Y, Lyu Z, Yang L, Ma L. “Reactive” optical sensor for Hg2+ and its application in environmental aqueous media and biological systems. Analytical and Bioanalytical Chemistry. 2017 Jan 26;409(9):2429–35. doi: 10.1007/s00216-017-0189-x.